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MRI Imaging Report Comparison: NIH vs. Old Protocols for PCKD Patients

This report details the comparison between the NIH protocol and an older MRI imaging protocol for two patients with polycystic kidney disease (PCKD). It highlights the differences in imaging techniques, including T2-Weighted and T1-Weighted multi-slice sequences. The NIH protocol utilized a single breathhold with 5mm slice thickness, while the older protocol used multiple breathholds with 3mm slices. Key observations include improved cyst resolution with 3mm slices, effective fat suppression, and the significance of coil placement in image quality. Additional considerations on breathhold duration and patient comfort are discussed.

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MRI Imaging Report Comparison: NIH vs. Old Protocols for PCKD Patients

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  1. NIH PCKD/Emory University MRI Imaging Report 1/31/2000

  2. Overview • 2 Patients Scanned with NIH Protocol • Both: Comparison with “Old Protocol” • Visual comparison • No SNR measurements performed • No Breathhold Flow Quantification (Yet) • Philips scanner should be capable • Little experience; Validation experiments?

  3. T2-Weighted Multi-Slice (#1) Old Protocol (3 mm) Multiple Breathholds NIH Protocol (5 mm) Single Breathhold

  4. T2-Weighted Multi-Slice (#2) Old Protocol (3 mm) Multiple Breathholds NIH Protocol (5 mm) Single Breathhold

  5. T2-Weighted Imaging: Remarks • 3 mm slice thickness resolves cysts better • Fat Suppression useful, works well • Multiple-breathhold: registration needed • Kidney “rigid object”: overlap + affine Xform • Avoid misregistration between interlaced stacks • Role in image analysis?

  6. T1-Weighted 3-D (PRE-#1) Old Protocol (2.5/5 mm) =40 Single Breathhold NIH Protocol (2.5/5 mm) =12 Single Breathhold

  7. T1-Weighted 3-D (PRE-#2) Old Protocol (2.5/5 mm) =40 Single Breathhold NIH Protocol (2.5/5 mm) =12 Single Breathhold

  8. T1-Weighted 3-D (POST-#1) Old Protocol (2.5/5 mm) =40 90 s post-Gado NIH Protocol (2.5/5 mm) =12 120 s post-Gado

  9. T1-Weighted 3-D (POST-#2) Old Protocol (2.5/5 mm) =40 60 s post-Gado NIH Protocol (2.5/5 mm) =12 120 s post-Gado

  10. T1-Weighted 3-D heart liver Ghost artifact due to heart motion (?) Apply pre-saturation slab anterior to volume to reduce intensity?

  11. T1-Weighted Imaging: Remarks • NIH protocol (=12) better overall SNR • Pre- & post-contrast: more complex image • Segmentation easier? (CNR measurements) • Coil placement important! Difficult? • Pre-saturation slabs? Added acq. time? • Older patients: • Many breathholds taxing to patient • Only 90 or 120 s post contrast?

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