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Exercise and CHD. What is cholesterol used for inside the body and how much do we need?. How is cholesterol involved with atherosclerosis?. Injury – HTN, inflammation, infection, trauma, toxic materials, etc. Fatty streak – monocytes form foam cells which become fatty streaks and plaques
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What is cholesterol used for inside the body and how much do we need?
How is cholesterol involved with atherosclerosis? • Injury – HTN, inflammation, infection, trauma, toxic materials, etc. • Fatty streak – monocytes form foam cells which become fatty streaks and plaques • Migration and aggregation – macrophages secret growth factors for smooth muscle cells, produce reactive oxygen materials which cause LDL to accumulate • Lipid accumulation • Maturation of the lesion