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Figure 1. Multiple Sol-Gel/Gel-Sol Transitions

T 1. pH Change. T 2 (>T 1 ). Active Control of Sol-Gel-Sol Transitions of Aqueous Solutions of Doubly Responsive Hydrophilic Block Copolymers Bin Zhao, University of Tennessee Knoxville, DMR 0906913.

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Figure 1. Multiple Sol-Gel/Gel-Sol Transitions

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  1. T1 pH Change T2 (>T1) Active Control of Sol-Gel-Sol Transitions of Aqueous Solutions of Doubly Responsive Hydrophilic Block CopolymersBin Zhao, University of Tennessee Knoxville, DMR 0906913 By incorporating stimuli-responsive groups into thermosensitve blocks, we have developed a unique class of doubly responsive hydrophilic block copolymers. The unique feature of these copolymers is that the lower critical solution temperature of thermosensitive blocks can be modified by external stimuli, enabling active control of sol-gel/gel-sol transitions. In particular, the sol-gel transition temperature of aqueous solutions of thermo- and pH-sensitive block copolymers can be precisely tuned (Figure 1). Scheme 1 illustrates the formation and dissociation of micelles of an T- and pH-sensitive ABA triblock copolymer in water. The doubly responsive block copolymer micellar gels developed from this project can be used in biomedical and other technological applications. Figure 1. Multiple Sol-Gel/Gel-Sol Transitions Macromolecules2009, 42, 8468; 2009, 42, 9369; 2010, 43, 5387. Langmuir2010, 26, 8787. Soft Matter 2010, 6, 3325. Scheme 1. Multiple Micellization/Dissociation Transitions

  2. Active Control of Sol-Gel-Sol Transitions of Aqueous Solutions of Doubly Responsive Hydrophilic Block Copolymers Bin Zhao, University of Tennessee Knoxville, DMR 0906913 Education Under current & previous grants, three students have graduated with Ph.D. degrees (Dejin Li, 2008; Xueguang Jiang, 2010; Xiaoming Jiang, 2010). Four students are pursuing their Ph.D. degrees: Thomas O’Lenick (5th year), Jeremiah Woodcock (4th year), Jon Horton (3rd year), and Naixiong Jin (2nd year). Three undergraduates participate in this project (Roger Wright, Mason Gindt, and Samuel Goddard). Amie Guo, a high school student from Farragut High School of Knoxville, is doing experiments in the lab. • Outreach • Hosted one high school student, Amie Guo, in • the laboratory in the summer and fall semesters • of 2009 (06/2009 ~ 12/2009). Using ATRP, she • made thermosensitive ABA copolymers and • studied sol-gel transitions. Amie presented her • results in her school. She will attend MIT. • Hosted two high school teachers, Mr. Josh • Nelson and Ms. Debbie Fraser, for two weeks in • the summer of 2009 and worked with them to • develop experiments for their classes. Josh Nelson, a chemistry teacher from Farragut High School of Knoxville, is doing experiments in the lab.

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