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Eric Niederhoffer SIU-SOM

What is the role of the pentose phosphate pathway?. Eric Niederhoffer SIU-SOM. NADPH production Glutathione reduction (E), fatty acid/cholesterol synthesis (L) Glycolytic intermediates Fructose-6-phosphate, glyceraldehyde-3-phosphate Ribose-5-phosphate

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Eric Niederhoffer SIU-SOM

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  1. What is the role of the pentose phosphate pathway? Eric Niederhoffer SIU-SOM

  2. NADPH production Glutathione reduction (E), fatty acid/cholesterol synthesis (L) Glycolytic intermediates Fructose-6-phosphate, glyceraldehyde-3-phosphate Ribose-5-phosphate Nucleotide synthesis (nucleated cells) Overview

  3. Glycolysis and Pentose Phosphate Pathways H2O2 H2O GSH GP HK Glc G6P NADP+ + H+ GSSG PGI GR F6P Glycolysis NADPH PFK F16BP aldolase CO2 G6PDH lactonase 6PGDH DHAP + G3P G3PDH 1,3-BPG 6PG PGK PPP 3PG PGM 2PG 3-7 C metabolites (R5P, F6P, G3P) enolase PEP PK Pyr

  4. HK PGI Glucose G6P F6P G6PDH NADP+ NADP+ NADPH NADPH 6PGL • FA/cholesterol synthesis lactonase • RBC ox stress 6PG 6PGDH CO2 Ru5P Oxidative Phase

  5. Ru5P RuP3E R5PI F6P Xu5P R5P TK G3P E4P S7P Glycolysis Nucleotides TA TK F6P G3P Non-oxidative Phase

  6. What are the main functions of the pentose phosphate pathway? Which enzymes produce NADPH? Which intermediates can feed back into the glycolytic pathway? Review Questions

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