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Eric Niederhoffer SIU-SOM

A 38-year-old woman is brought to the physician because of frequent falls, increasing confusion, and incontinence. How does ethanol ingestion cause nutrition problems?. Eric Niederhoffer SIU-SOM. Cellular processing Pathway perturbations Malate-aspartate shuttle Glycerol-3-phosphate shuttle.

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Eric Niederhoffer SIU-SOM

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  1. A 38-year-old woman is brought to the physician because of frequent falls, increasing confusion, and incontinence How does ethanol ingestion cause nutrition problems? Eric Niederhoffer SIU-SOM

  2. Cellular processing Pathway perturbations Malate-aspartate shuttle Glycerol-3-phosphate shuttle Alcohol Metabolism and Effects

  3. Peroxisome Cytosol H2O2 NAD+ ER CAT O2 ADH MEOS NADPH Pyrazole H2O P450 NADH Aminotriazole NADP+ NAD+ Mitochondrion AlDH NADH Disulfiram (antabuse) Chlorpropamide (diabetes) Extra-hepatic tissue Cellular Processing EtOH Acetaldehyde Acetate

  4. β-Ox NADH FA NADH NADH NADH Pathway Perturbations Glc Glycolysis Gluconeogenesis G6Pase GK G6P Cytosol Protein F6P F16BPase PFK Ala F16BP Asp PEPCK OAA PEP ALT AST NAD+ NAD+ PK MDH LDH MDH Lactate Pyr Malate OAA NADH NADH NADH PDH PC Acetyl CoA Malate NAD+ MDH OAA Cit NADH Malate ICit Mitochondrion ICDH Fum NAD+ NAD+ αKGDH Suc αKG S CoA

  5. IMS IM Matrix CI Asp Asp αKG αKG AST AST Glu Glu OAA OAA NADH NADH MDH MDH NAD+ NAD+ Mal Mal Malate-Aspartate Shuttle(liver, kidney, heart) GT MaT

  6. IMS IM Matrix NAD+ G3P FAD G3PDH FADH2 Q NADH DHAP CIII Glycerol-3-Phosphate Shuttle(skeletal muscle, brain)

  7. How is ethanol detoxified (enzymes, cofactors, products, location)? Which metabolic pathways are affected by alcohol-derived NADH (enzymes, metabolites)? What are useful (important) clinical markers? How does the cell process NADH? Review Questions

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