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Monday, 26 November 2012

Monday, 26 November 2012. This is best viewed as a slide show. To view it, click Slide Show on the top tool bar, then View show. Monday, 26 November 2012. Overview Do it. This is best viewed as a slide show. To view it, click Slide Show on the top tool bar, then View show. The Goal.

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Monday, 26 November 2012

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  1. Monday, 26 November 2012 This is best viewed as a slide show.To view it, click Slide Show on the top tool bar, then View show.

  2. Monday, 26 November 2012 • Overview • Do it This is best viewed as a slide show.To view it, click Slide Show on the top tool bar, then View show.

  3. The Goal Trypanosomes

  4. Prediction of model G6P numericalsimulation The Goal Metabolic model ...

  5. external pyruvate external glucose Prediction Numerical simulation(glycolysis.pl)

  6. NewPrediction Numerical simulation(glycolysis.pl) external glucose

  7. How do you know when you’re done? NewPrediction Numerical simulation(glycolysis.pl) external glucose

  8. How do you know when you’re done? Necessary?

  9. How do you know when you’re done? Necessary?

  10. How do you know when you’re done?

  11. How do you know when you’re done? Rene Descartes I think, therefore I am

  12. How do you know when you’re done? Trypanosome I am,therefore I’m at steady state

  13. How do you know when you’re done?

  14. fructose bisphosphate How do you know when you’re done? Metabolic model NewPrediction ? external glucose What do you predict about other metabolites?

  15. How do you know when you’re done?

  16. How do you know when you’re done?

  17. fructose bisphosphate How do you know when you’re done? Metabolic model NewPrediction ? external glucose What do you predict about other metabolites?

  18. How do you get started? Working on the program in class and getting one on one help would be nice. Goals • Stop accumulation of FBP

  19. How do you get started? Working on the program in class and getting one on one help would be nice. Goals • Stop accumulation of FBP • Fix underlying problem Notes Nov 21 Account for missing or unconstrained metabolites Notes Nov 26 Compartments and separate pools

  20. How do you get started? Working on the program in class and getting one on one help would be nice. Goals • Stop accumulation of FBP • Fix underlying problem • Achieve steady state

  21. How do you get started? Working on the program in class and getting one on one help would be nice. Goals • Stop accumulation of FBP • Fix underlying problem • Achieve steady state • THEN worry about inhibition

  22. Overview of Eisenthal and Cornish-Bowdin

  23. Modeling GlycolysisUsing data of Eisenthal & Cornish-Bowdin SQ14. Identify the source of the constants in the program segment entitled “Rate constants and equilibrium ratios”. V+ and V- are velocity fwd and reverse?

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