Special NIH Funding Opportunities

1. Special NIH Funding Opportunities Elizabeth Wilder, Ph.D. Director Office of Strategic Coordination Division of Program Coordination, Planning, and Strategic Initiatives Office of the NIH Director March 12, 2014 http://www.commonfund.nih.gov

2. 27 NIH Institutes and Centers Clinical Center National Institute of Deafness and Communications Disorders NIAMS National Institute of Arthritis and Musculoskeletal and Skin Diseases International Center National Institute of Biomedical Imaging and Bioengineering National Institute of Diabetes and Digestive and Kidney Diseases

3. The Office of the Director (OD)

4. Current Common Fund Programs Extracellular RNA Communication Undiagnosed Diseases Program NIH Common Fund Strengthening the Biomedical Research Workforce Health Economics PROMIS: Clinical Outcomes Assessment Big Data to Knowledge (BD2K) Single Cell Analysis Regulatory Science NIH Center for Regenerative Medicine Enhancing the Diversity of the NIH-Funded Workforce The 4D Nucleome Glycoscience NIH Medical Research Scholars Protein Capture Gulf Oil Spill Long Term Follow Up Human Microbiome Nanomedicine HCS Research Collaboratory High-Risk Research Knockout Mouse Phenotyping Global Health Pioneer Awards New Innovator Awards Transformative Research Awards Early Independence Awards Illuminating the Druggable Genome Structural Biology Building Blocks, Biological Pathways And Networks Science of Behavior Change Library of Integrated Network- Based Cellular Signatures (LINCS) Metabolomics Genotype- Tissue Expression Epigenomics http://commonfund.nih.gov/

5. Criteria for Common Fund Programs Common Fund program areas are selected through a strategic planning process that identifies trans-NIH challenges or areas of exceptional opportunity that meet the following criteria: Transformative:Must have potential for exceptionally high impact — to dramatically affect biomedical and/or behavioral research over the next decade Synergistic:Outcomes must synergize with research supported by the NIH Institues and Centers (ICs) to promote and advance individual missions of ICs and to benefit health Catalytic: Must achieve a defined set of goals within 5-10 years which will then catalyze further work supported by the ICs Cross-Cutting:Program areas must cut across missions of multiple NIH ICs. Similarly, programs must be relevant to multiple diseases or conditions Unique:Must be something no other entity is likely or able to do, or, if similar efforts exist, the Common Fund programs must be coordinated with others. The CF supports projects that would be unlikely to be supported through traditional, investigator-initiated mechanisms. FY11 Budget: $543M

6. CF Programs Build “Foundations” to Catalyze Research • ■ New Approaches to Foster Innovation and Invigorate the Research Workforce • ■ High-Risk High-Reward (Pioneer, New Innovator, Transformative Research, Early Independence Awards) • ■ Broadening Experiences in Scientific Training (BEST) Awards (New in FY13) • ■ Enhancing Diversity in the NIH-funded Workforce (New in FY13) • ■ New Tools, Infrastructure, and Data to Support or Establish New Fields of Study • ■ Extracellular RNA Communication • ■ Epigenomics • ■ Knock-Out Mouse Phenotyping Project (KOMP2) • ■ Illuminating the Druggable Genome (New in FY14) • ■ New Technologies and Approaches to Overcome Barriers to Progress in a Field • ■ Structural Biology • ■ PROMIS: Patient Report Outcomes Management System • ■ Microphysiological Systems for Drug Screening

7. High-RiskHigh-Reward(HRHR) Research New approaches to support exceptionally creative scientists who propose highly innovative approaches to major contemporary challenges in biomedical research Novel approaches to peer review and funding mechanisms • Preliminary data not required • Shortened application • Transformative Research Awards allow multi-disciplinary teams of investigators TRA

8. High-Risk High-Reward (HRHR) Research Awards TRANSFORMATIVE RESEARCH EARLY INDEPENDENCE PIONEER NEW INNOVATOR Junior investigators (within 1 year of Ph.D. or medical residency) Who? All career stages, applications from teams of investigators welcome All career stages Early stage Investigators Transformative ideas that may involve large budgets Creative scientists proposing paradigm shifting research Early stage investigators proposing high potential impact research Junior scientists ready for research independence What? All areas of basic, clinical and translational science within the NIH mission Budget? Up to $25 million per year for 5 years Up to $500,000 per year for 5 years Up to $300,000 per year for 5 years Up to $250,000 per year for 5 years Preliminary data requirements less stringent than R01 award Prelim data? Preliminary data not required Preliminary data not required Preliminary data not required For more information: http://commonfund.nih.gov/highrisk

9. High-Risk High-Reward (HRHR) Research Awards TRANSFORMATIVE RESEARCH EARLY INDEPENDENCE We WILL have all 4 competitions again next year! http://COMMONFUND.nih.gov/ We WILL have all 3 competitions again next year! Look for announcements next spring. http://nihroadmap.nih.gov/ PIONEER NEW INNOVATOR Junior investigators (within 1 year of Ph.D. or medical residency) Who? All career stages, applications from teams of investigators welcome All career stages Early stage Investigators Transformative ideas that may involve large budgets Creative scientists proposing paradigm shifting research Early stage investigators proposing high potential impact research Junior scientists ready for research independence What? All areas of basic, clinical and translational science within the NIH mission Budget? Up to $25 million per year for 5 years Up to $500,000 per year for 5 years Up to $300,000 per year for 5 years Up to $250,000 per year for 5 years Preliminary data requirements less stringent than R01 award Prelim data? Preliminary data not required Preliminary data not required Preliminary data not required For more information: http://commonfund.nih.gov/highrisk

10. CF Programs Build “Foundations” to Catalyze Research • ■ New Approaches to Foster Innovation and Invigorate the Research Workforce • ■ High-Risk High-Reward (Pioneer, New Innovator, Transformative Research, Early Independence Awards) • ■ Broadening Experiences in Scientific Training (BEST) Awards (New in FY13) • ■ Increasing Diversity in the NIH-funded Workforce (New in FY13) • ■ New Tools, Infrastructure, and Data to Support or Establish New Fields of Study • ■ Extracellular RNA Communication • ■ Epigenomics • ■ Knock-Out Mouse Phenotyping Project (KOMP2) • ■ Illuminating the Druggable Genome (New in FY14) • ■ New Technologies and Approaches to Overcome Barriers to Progress in a Field • ■ Structural Biology • ■ PROMIS: Patient Report Outcomes Management System • ■ Microphysiological Systems for Drug Screening

11. Extracellular RNA Communication Trans-NIH Involvement: -- Led by NCI and NCATS -- Working Group Members from 18 Institutes/Centers

12. Epigenomics: Data and Resources for the Biomedical Research Community http://www.roadmapepigenomics.org/ • Reference epigenome maps • Technology development • Discovery of novel marks • Epigenomic basis of disease • International coordination • Data sharing • Standards For more information: http://commonfund.nih.gov/epigenomics/

13. Knockout Mouse Phenotyping Program (KOMP2) Database Web server Mouse Production ■ Partnership with International Mouse Phenotyping Consortium (IMPC) ■ Standardized, broadphenotyping of 5,000 KO mice derived from IKMC ES cells ■ Definition of in vivo function of mammalian genes and identification of new models of disease ■Data stored in a centralized database (European Molecular Biology Lab) Mice/Embryos KOMP Repository Tracking Analysis Display Microinjection Germline Transmission LacZ staining Lethality/Fertility Cryopreservation KOMP ES cells EuCOMM ES cells Mice/Embryos Data ES cells Data Mice/Embryos Cohort breeding Phenotyping Data Upload Cohort breeding Phenotyping Data Upload Nominate a gene for phenotyping athttp://www.kompphenotype.org/ Cohort breeding Phenotyping Data Upload Learn about the international effort at http://www.mousephenotype.org/ KOMP2Phenotyping Process Mouse Phenotyping Center(s) For more information: http://commonfund.nih.gov/KOMP2/

14. Knowledge Management Center:What do we know, and what do we need to know about members of these protein families? • IDG: Understanding the properties and functions of poorly characterized proteins from 4 protein families that are the most common drug targets • G-Protein Coupled Receptors • Nuclear Receptors • Ion Channels • Protein Kinases

15. CF Programs Build “Foundations” to Catalyze Research • ■ New Approaches to Foster Innovation and Invigorate the Research Workforce • ■ High-Risk High-Reward (Pioneer, New Innovator, Transformative Research, Early Independence Awards) • ■ Broadening Experiences in Scientific Training (BEST) Awards (New in FY13) • ■ Increasing Diversity in the NIH-funded Workforce (New in FY13) • ■ New Tools, Infrastructure, and Data to Support or Establish New Fields of Study • ■ Extracellular RNA Communication • ■ Epigenomics • ■ Knock-Out Mouse Phenotyping Project (KOMP2) • ■ New Technologies and Approaches to Overcome Barriers to Progress in a Field • ■ Structural Biology • ■ PROMIS: Patient Report Outcomes Management System • ■ Microphysiological Systems for Drug Screening

16. Regulatory Science: Improving the process for developing new therapies • Human-on-a-Chip – a collaborative initiative between NIH, DARPA, and FDA for improved toxicity and efficacy testing • Ten microphysiological systems to be represented on an integrated platform • Must replicate known responses to drugs and toxins • Must allow sustained analysis – up to 4 weeks – with multiple read-outs • Should be extendable to include mimics of pathology • NIH to encourage development of more accurate representations of physiology and pathology • NIH will also encourage development of microsystems from iPS cells

18. For more information: http://commonfund.nih.gov/ Contact information: Today’s talk – Betsy Wilder betsywilder@nih.gov Pioneer, TR01, New Innovators, Early Independence Award – Ravi Basavappa basavapr@od.nih.gov Other Questions: Ellie Murcia murciae@od.nih.gov 18

19. Thank you! Any Questions?