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Understanding Influenza A Virus: Mechanisms and Health Impacts

This presentation by Celline Kim in 2009 explores the Influenza A virus, examining its transmission, the immune response it triggers, and the effects of various substances, like 4-nonylphenol, on immune cells. It discusses significant studies that illuminate the impacts of environmental pollutants on influenza's effects on health, emphasizing the importance of understanding these interactions. This work aims to enhance awareness of viral infections and the role of chemical exposure in influencing immune responses, ultimately aiming to protect public health.

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Understanding Influenza A Virus: Mechanisms and Health Impacts

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  1. No, they won’t infect you…… Celline Kim----------------------Final Presentation-----------------------------------2009

  2. http://upload.wikimedia.org/wikipedia/commons/thumb/3/30/Influenza-2009-cases.png/350px-Influenza-2009-cases.pnghttp://upload.wikimedia.org/wikipedia/commons/thumb/3/30/Influenza-2009-cases.png/350px-Influenza-2009-cases.png

  3. http://s.wsj.net/public/resources/images/NA-AX653D_NUMBG_NS_20090512230421.gifhttp://s.wsj.net/public/resources/images/NA-AX653D_NUMBG_NS_20090512230421.gif

  4. Influenza A virus

  5. http://images.google.com/imgres?imgurl=http://www.csa.com/discoveryguides/avian/images/replication.gif&imgrefurl=http://www.csa.com/discoveryguides/avian/review3.php&usg=__8aC1jIDCy6wYZf5l12BxzsjZU=&h=480&w=450&sz=28&hl=en&start=3&um=1&tbnid=1fT3bBgZsGeL5M:&tbnh=129&tbnw=121&prev=/images%3Fq%3Dinfluenza%2Ba%2Bvirus%26hl%3Den%26safe%3Dstrict%26um%3D1http://images.google.com/imgres?imgurl=http://www.csa.com/discoveryguides/avian/images/replication.gif&imgrefurl=http://www.csa.com/discoveryguides/avian/review3.php&usg=__8aC1jIDCy6wYZf5l12BxzsjZU=&h=480&w=450&sz=28&hl=en&start=3&um=1&tbnid=1fT3bBgZsGeL5M:&tbnh=129&tbnw=121&prev=/images%3Fq%3Dinfluenza%2Ba%2Bvirus%26hl%3Den%26safe%3Dstrict%26um%3D1

  6. Vasquez, 03 SURFACTANTS http://images.google.com/imgres?imgurl=http://www.unitedlabsinc.com/usa/images/npe_free/npe_chart.gif&imgrefurl=http://www.unitedlabsinc.com/usa/content/about_us/npe_free.asp&usg=__8ZTqFaA1DenxgOMdhyvSVGmveIw=&h=474&w=600&sz=44&hl=en&start=3&um=1&tbnid=ANcGO9gqyuwVKM:&tbnh=107&tbnw=135&prev=/images%3Fq%3Dnonylphenol%2Bethoxylates%26hl%3Den%26safe%3Dstrict%26sa%3DN%26um%3D1

  7. Novosad, 2002 Acta Medica Journal http://twocw.educities.edu.tw/cocw/mit/NR/rdonlyres/Health-Sciences-and-Technology/HST-176Fall-2005/CDAE7761-966D-4287-B0E0-F327299C6584/0/chp_apopmicro.jpg

  8. Idea Summation • Influenza stimulates • 4-NP suppresses • Gene of interest: Sialic Acid Binding Ig-like lectin 12 • U937 (ATCC) • 4-NP + Estrogen

  9. Bibliography Novosad J, Fiala Z, Borska L, Krejsek J. Immunosuppressive effect of polycyclic aromatic hydrocarbons by induction of apoptosis of pre-B lymphocytes of bone marrow. Acta Medica (Hradec Kralove). 2002;45(4):123–128. Eva C. Bonefeld-Jørgensen,1 Manhai Long,1 Marlene V. Hofmeister,1 and Anne Marie Vinggaard. Endocrine-Disrupting Potential of Bisphenol A, Bisphenol A Dimethacrylate, 4-n-Nonylphenol, and 4-n-Octylphenol in Vitro: New Data and a Brief Review. Environ Health Perspect. 2007 December; 115(S-1): 69–76. Bonefeld-Jorgensen EC, Ayotte P. AMAP Assessment 2002: Human Health in the Arctic. Oslo, Norway: Arctic Monitoring and Assessment Programme; 2003. Toxicological properties of POPs and related health effects of concern for the Arctic populations; pp. 57–74. Bjornstrom L, Sjoberg M. Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes. Mol Endocrinol. 2005;19(4):833–842. Fries, E., Puttmann, W. The dissipation, distribution and fate of a branched C14-nonylphenol isomer in lake water/sediment systems. Hoponick, Jenny. Nonylphenol Ethoxylates. Sierra Club. 2005. Jung, Mi Young, Kim, Tae Sung. Differential modulation of regulatory T cell activities by nonylphenol, octylphenol, and diethylstilbestrol. The Journal of Immunology. 2009. 182:47.3. The American Association of Immunologists. Yao, Genhong, and Hou, Yayi. Nonylphenol induces thymocyte apoptosis through Fas/FasL pathway by mimicking estrogen in vivo. Environmental Toxicology and Pharmacology. May 2004. Volume 17, Issue 1. P. 19-27. Moran, TM, Isobe, H, Fernandez-Sesma, A, Schulman, JL. Interleukin-4 causes delayed virus clearance in influenza virus-infected mice. Department of Microbiology. Journal of Virology. August 1996, 5230-5235. Vol 70, No.8. Ludwig, S, Ehrhardt, C, Neumeier, E.R., Kracht, M., Rapp, U.R., Pleschka, S. Influenza virus-induced AP-1-dependent gene expression requires activation of the JNK signaling pathway. Journal of Biology and Chemistry. April 2001. Vol. 276, Issue 14, 10990-10998.

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