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Genetic Diseases Pedigree Analysis Lesson

Explore Huntington's Disease, Sickle Cell Anemia, and Hemophilia using a pedigree. Create your own family pedigree with traits analysis.

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Genetic Diseases Pedigree Analysis Lesson

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  1. March 29, 2012 Mrs. Anna Ward James Martin MS

  2. DO NOW!!! • How many males are present? • How many females are present? • How many generations? • How many children does the first generation (I) couple have? • How many marriages are represented? • How many males have the disease? • How many females have the disease? In the Pedigree to the Right, tell me….

  3. Announcements • Don’t forget Pass Expectations • Schedule for today: • 9:15 - 10:15  Cougar Time • 10:20 - 11:20 2nd Period • 11:25 - 12:55: 3rd Period • 12:20 - 12:50 Lunch • 1:00 - 1:55 4th Period • 2:00 - 3:00 5th Period • 3:05 - 4:15 CELEBRATION! (Johnson & Rodriguez's Room)

  4. Agenda • Huntington’s Disease • Sickle Cell Anemia • Hemophilia • Create your own PEDIGREE

  5. Huntington’s Disease • Huntington's disease is a genetic disorder passed down through families in which nerve cells in certain parts of the brain waste away, or degenerate.

  6. Huntington’s Disease • If one of your parents has it, you have a 50% chance of getting it. • Onset of the symptoms usually starts around age 40. • One of the common traits marked in pedigrees • First Genetic Disease Mapped to a Chromosome (#4)

  7. Huntington’s Disease • http://www.youtube.com/watch?v=65xf1olEpQM

  8. Huntington’s Disease • Why do you think it would be important to use a Pedigree to track Huntington’s Disease??? • What do you notice about this Pedigree?

  9. SICKLE CELL DISEASE • Sickle cell anemia is a disease passed down through families in which red blood cells form an abnormal crescent shape. (Red blood cells are normally shaped like a disc.) • http://www.youtube.com/watch?v=iKQmQHh4E2w&feature=related • http://www.youtube.com/watch?v=qe59ar-GZmg

  10. SICKLE CELL DISEASE • Sickle Cell Pedigree: • HOW IS THIS DIFFERENT FROM THE PEDIGREE FOR HUNTINGTONS?

  11. HEMOPHILIA • Hemophilia refers to a group of bleeding disorders in which it takes a long time for the blood to clot. • Known as the “ROYAL DISEASE” from the infamous Russian Royal Family

  12. HEMOPHILIA • http://player.discoveryeducation.com/index.cfm?guidAssetId=A6AC1338-DEC9-4AA1-AEED-18BCAE0239DB&blnFromSearch=1&productcode=US

  13. Royal Family Pedigree

  14. CREATE YOUR OWN PEDIGREE • Think of a trait that some (but not all) of your family members carry. • Some examples may be: • Left-Handedness • Curly Hair • Tongue Rolling • Widow’s Peak • Attached Earlobes • Freckles • Allegies • Cleft Chin • …….

  15. SECOND STEP… • Begin By Drawing your family members, using a • CIRCLE—Women/girls • SQUARE—Men/Boys • DO NOT SHADE ANYTHING AT THIS POINT Here is a diagram to help you remember how to draw one:

  16. THIRD STEP • If anyone is deceased, Make a diagonal slash mark through their circle or square. • Then use a Marker to Color in any family member with the trait. • If you do not know the trait for sure, you can take it home and complete it over the weekend.

  17. FOURTH STEP • Label your pedigree with your name, your family name • Place a “key” at the bottom or side indicating what each shape means.

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