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A Brief History of Assisted Reproductive Technology

A Brief History of Assisted Reproductive Technology. University of Cambridge 1963-1965. Spontaneous meiosis Multiple species The road taken Human sperm meets human egg No fertilization. Johns Hopkins University Baltimore 1965. Parameters of spontaneous human meiosis

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A Brief History of Assisted Reproductive Technology

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  1. A Brief HistoryofAssisted Reproductive Technology

  2. University of Cambridge1963-1965 • Spontaneous meiosis • Multiple species • The road taken • Human sperm meets human egg • No fertilization

  3. Johns Hopkins UniversityBaltimore 1965 • Parameters of spontaneous human meiosis • Capacitation – the key to fertilization • Washed sperm (swim up) • Cervical mucus • Endometrium • Fallopian tube • Rabbit • Cynomolgus monkey

  4. How the Sperm Metthe Egg in Norfolk By a Telephone Call

  5. Conventional Wisdom1980 • Use the natural cycle • Inseminate as quickly as possible • Transfer at eight-cell stage • Transfer at night

  6. Unknown PhysiologyJanuary 1980 • LH surge to ovulation • Cumulus detachment • Maturation at ovulation • Rate of in vitro development

  7. Unknown DetailsJanuary 1980 • Optimum 02 tension • Optimum pH • Light sensitivity? • Temperature requirement • Aspiration pressure • Needle diameter bevel length

  8. Results - 1980 ND = Not Determined

  9. Early Studies(date published) • Prediction of ovulation in the normal menstrual cycle (1981) • The blizzard needle (1981) • The ethics of IVF (1981)

  10. Beginning of LH Surge to Aspiration Beginning of LH Surge to Aspiration

  11. Stimulated CyclesWorld Data – December 1980 Oldham 1978 Melbourne 1980 Stimulations Aspirations Transfers Pregnancies Deliveries NA NA 77 3 0 NA NA 48 3 0 Lapota, Nature 1980; 298:642

  12. HMG Really Does WorkThe first hMG baby by IVF

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