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ARTHRITIS

ARTHRITIS. Rheumatoid Arthritis Presented By: Ali Raza Ansar Qudsia Sehar Hafsa Kabir. Introduction. Joint disorder that cause inflammation Over 100 types of Arthritis Most Common is Rheumatoid Arthritis and osteoarthritis, both are autoimmune diseases. Symptoms

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ARTHRITIS

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  1. ARTHRITIS Rheumatoid Arthritis Presented By: Ali RazaAnsar QudsiaSehar HafsaKabir

  2. Introduction • Joint disorder that cause inflammation • Over 100 types of Arthritis • Most Common is Rheumatoid Arthritis and osteoarthritis, both are autoimmune diseases. • Symptoms • Inability to use the hand or walk • Malaise and a feeling of tiredness • Weight loss • Poor sleep • Muscle aches and pains • Tenderness • Difficulty moving the joint

  3. Biology Of Rheumatoid Arthritis • Genetic Basis of RA: • HLA genes: HLA-DR1 and DR4 are associated with disease • PDAI: Peptidyl arginine deaminase gene • PTN22 gene: Regulates kinases • Autoantibodies: • Rh factor: Antibody, binds to the Fc region of IgG.

  4. ACPA: Anti-citrullinated protein antibody, MHC class-II, specially bearing “shared epitope” bind efficiently with citrullinated proteins. An immune response is triggered producing ACPA. • Inflammation and bone deformity: • Different cytokines are involved • IL-1, IL-6 and TNFα are important • Normal bone remodeling • Osteoblasts • Osteoclasts • NF-κB plays significant role in RA pathogenesi • Role of estrogen

  5. Diagnosis of ArthritisDiagnostic Tools • Physical Examination • Laboratory Tests • Medical Imaging

  6. Laboratory Tests • Rheumatoid factor • Erythrocyte sedimentation Rate • C-reactive protein • Anti-cyliccitullinatedPeptide Antibody Test • Antinuclear Antibodies • Compete blood count

  7. Treatment • Drug treatment • Occupational/physical therapy • Surgery • Biologics

  8. Drug Treatment • Pain killers • NSAID’S (non-steroidal anti inflammatory drug) • Cox-2 inhibitors • Gold injections

  9. Physical therapy • Surgery Performed when patients are non-responsive for treatment

  10. Biotechnological Applications in Treatment • Biologics • Use specifically for rheumatoid arthritis • Target specific • Act only on immune system • Anti- t.f is an example

  11. Current Research Projects • DEVELOPMENT OF ANTISENSE THERAPY OF ARTHRITIS • DEVELOPMENT OF A BIOMARKER FOR RA

  12. Development of Antisense Therapy of Arthritis • Developed by BGN technologies • Target cPLA-2 • Inhibits the synthesis of c-PLA 2 ENZYME

  13. Development of a Biomarker For RA • RA biomarker based on 14-3-3η protein • It is an intracellular protein • Suffering from RA it is involved in joints deformation and is released inside joints

  14. QUESTIONS

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