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Drug Metabolizing Enzyme Genotype(s) and Chemotherapeutic Outcome(s)

Drug Metabolizing Enzyme Genotype(s) and Chemotherapeutic Outcome(s). Nasir Ali Afsar MBBS, M.Phil College of Medicine, Alfaisal University, Riyadh. Acknowledgement. Dedicated to my mentors in recognition to what I learned from them:. Professor Ingolf Cascorbi, Kiel, Germany. and

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Drug Metabolizing Enzyme Genotype(s) and Chemotherapeutic Outcome(s)

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  1. Drug Metabolizing Enzyme Genotype(s) and Chemotherapeutic Outcome(s) Nasir Ali Afsar MBBS, M.Phil College of Medicine, Alfaisal University, Riyadh.

  2. Acknowledgement

  3. Dedicated to my mentors in recognition to what I learned from them: Professor Ingolf Cascorbi, Kiel, Germany. and Professor H R Ahmad, Karachi, Pakistan.

  4. Treatment of a Disease

  5. Clinical and Economic Importance of Therapeutic Response Jackson DB. 2009; Drug Discovery Today doi:10.1016/j.drudis.2009.01.006

  6. Solution Assessment and Reflection Optimized Therapy Modeling Molecular Evaluation (SNPs, Expression etc.) Clinical Evaluation (Efficacy vs. ADRs) Patient Characterization Jackson DB. 2009; Drug Discovery Today doi:10.1016/j.drudis.2009.01.006

  7. Central Dogma

  8. Available Literature: Oncology and Genetics

  9. Disease Free Survival vs. Genotype:Nonspecific xenobiotic metabolizing enzymes GSTA1 Sweeney C et al. 2003. Int. J. Cancer. 103, 810–814

  10. Disease Free Survival vs. Genotype:Cell signalling and differentiation Sánchez-Navarro I et al. 2010. BMC Cancer. 10:336

  11. Treatment Response vs. Genotype Bonnefoi et al. 2007. Lancet Oncol. 8: 1071–78

  12. Systemic Drug Exposure vs. Treatment Response vs. Genotype Petros WP et al. 2005. J Clin Oncol. 23:6117-6125

  13. Pharmacokinetics vs. Genotype p = 0.02 p = 0.02 ke (h–1) n= 38 8 3 *1/*1 *1/*2 *2/*2 CYP2C19 Genotype Timm et al. 2005. Pharmacogenomics J. 5, 365-373

  14. Pharmacokinetics vs. Genotype CYP2C19 Genotype Ekhart C et al. 2008. Pharmacogenet Genomics. 18, 515-23

  15. Pharmacokinetics vs. Genotype Bunting KD et al. 1996. J Biol Chem. 271, 11891-96

  16. Pharmacokinetics vs. Genotype Afsar NA et al. Unpublished Data

  17. Pharmacokinetics vs. Genotype Afsar NA et al. Unpublished Data

  18. Pharmacokinetics vs. Genotype Afsar NA et al. Unpublished Data

  19. Does genotyping suffice?

  20. Drug Metabolizing Enzyme Genotype(s) and Chemotherapeutic Outcome(s) nafsar@alfaisal.edu drnasirpk@yahoo.com

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