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Wed. Sept 5

Wed. Sept 5. Metabolism -- ~ P Homeostasis. The Measurement of Metabolism. We will not directly follow these processes any more than a chemist does who measures the heat evolved or taken in by a process.

nayda-cobb
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Wed. Sept 5

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  1. Wed. Sept 5

  2. Metabolism -- ~P Homeostasis

  3. The Measurement of Metabolism We will not directly follow these processes any more than a chemist does who measures the heat evolved or taken in by a process. Methods all involve assumptions -- in a way it is like measuring the economy and no one measure is perfect.

  4. Phosphagen Cycle -- Phosphagen Buffer During High Demand This process is controlled by the amount of enzyme present (CK) and thermodynamically (amts. of reactants/products)

  5. Replenishment of Phosphagen

  6. The Krebs Cycle • Take Home: • Occurs in the mitochondrial matrix • Rate is very dependent on the ratio of oxidized to reduced coenzyme • Feed ins -- 2 C frags.. from carbohydrate and fat metabolism; • Amino acid frags in other places

  7. Energy Schematic of the ETS • Take Home • In inner membrane • Will maintain a favorable steady-state ratio of oxidized to reduced coenzyme if sufficient O2 is present to accept each electron produced in the Krebs and other reactions.

  8. Mitochondrial Overall Energy Schematic

  9. Glycolysis EnergySchematic

  10. Aerobic Glycolysis Overview

  11. Energetics of Aerobic Glycolysis The overall reaction (path does not matter): A distinct stoichiometry exists between all members of this process. This means that if we know carbohydrate is the fuel, then if we measure the change in one component of this reaction, we know the changes in all others.

  12. How About Lipid? Once again, if we know that lipid (palmitic acid) is the fuel, we can measure one factor in the reaction and find all the others.

  13. How do we know the fuel being used? You cannot tell simply from what the animal eats. There is a certain ratio of CO2 production to O2 consumption exists for different fuels. For carbs: Ratio is 1:1

  14. The Ratio is Different In Palmitic Acid 16/23 = 0.7

  15. The Respiratory Quotient (RQ)

  16. How the Table Values For Energy EquivalenceWere Obtained – An example

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