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Xanthine Oxidase (XO)

Xanthine Oxidase (XO). 學生 : 李威聰 指導老師 : 李惠春. Introduction.  Function  Structure  Property  Gout. Function.  In purine degradation, it oxidizes hypoxanthine successively to xanthine and then to uric acid. Stucture.  Homodimer  Each monomer has three domains

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Xanthine Oxidase (XO)

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  1. Xanthine Oxidase (XO) 學生:李威聰 指導老師:李惠春

  2. Introduction Function Structure Property Gout

  3. Function In purine degradation, it oxidizes hypoxanthine successively to xanthine and then to uric acid

  4. Stucture  Homodimer  Each monomer has three domains N-terminal domain (residues 1~165): two Fe/S cofactors FAD-binding domain (residues 226~553) The third domain (residues 590~1332): one molybdenum

  5. Fe/S convert XDH (xanthine dehydrogenase) to XO FAD reduction of O2 Molybdenum oxidative hydroxylation of purine

  6. Property Ubiquitous among species and within the various tissues Normally it exists in the liver and jejunum determination of serum xanthine oxidase level serves as a sensitive indicator of acute liver damage

  7. In individuals, 90% is XDH form, and 10% is XO form  XDHXO (oxidation of sulfhydryl or proteolysis) Difference between XO & XDH: XO XH+H2O+O2X=O+H2O2 XDH XH+H2O+NAD+X=O+NADH

  8. Other names: xanthine oxidoreductase, hypoxanthine oxidase, hypoxanthine-xanthine oxidase

  9. Gout A form of arthritis caused by excess uric acid (hyperuricemia) Complication can result death Cause: heredity, diet, fatness, sex, excessive exercise, drug, alcohol, and some diseases

  10. Drug can decrease patients’ pains and prevent it an attack of acute gout: colchicine lower conc. of uric acid: allopurinol

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