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Framework for Rapid Prioritization

Learn about a research framework aiming to prioritize chemicals for safety testing based on exposure, using innovative approaches and sound science. The framework addresses gaps in knowledge and tools, aligning databases and tools to evaluate chemical exposures across their life cycles.

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Framework for Rapid Prioritization

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  1. Framework for Rapid Prioritization Linda Sheldon, Ph.D. Associate Director, National Exposure Research Laboratory April 6, 2010

  2. The Challenge • “Assure chemical safety in a rapidly changing world” • Too many chemicals too little data • 75,000 chemicals in TSCA inventory • 500 – 1000 new chemicals each year • Must modernize and strengthen the tools available for testing and prioritization • Based on hazard and exposure • Based on sound science • Must be transparent and understandable

  3. The Research Goal • To develop innovative approaches, tools, and enhanced scientific understanding to rapidly and effectively prioritize chemicals for further safety testing based on exposure

  4. The Research Approach • Develop a framework for chemical exposures • Align current databases, data collection protocols, and prioritization tools within the framework • Evaluate and compare existing prioritization tools • ID crucial gaps in our knowledge, data, approaches, and tools • Conduct scientific research to fill these gaps

  5. Framework Requirements Identify the chemicals and the scenarios associated with the highest exposures to categorize chemicals for further testing • Chemicals once created must go someplace • Evaluate release/exposures for chemicals across their life cycles • Account for physico-chemical properties and stability of • Chemical/intermediates • Environmental degradates • Metabolites – for in vitro assays such as Tox Cast • Incorporate spatial scales • Give special consideration to susceptible populations, especially children

  6. Life Cycle Stages Chemical Manufacture Chemical Transport Product Formulation Product Use Disposal Recycle

  7. RELEASE FATE/TRANSPORT CONCENTRATION ACTIVITY EXPOSURE Production Phases Chemical Manufacture WorkplaceExposure Water HumanExposure Food Chemical Transportation EnvironmentalRelease Land A C T I V I T I E S Air Production/Formulation(Product orProcessing Aid) EnvironmentalDisposal Incineration Recycling SewageTreatment PRODUCT USE SCENARIOS

  8. GLOBAL COUNTRY REGION LOCAL ENVIRONMENT backgroundconcentrations inflowconcentrations exchange Incorporation of Spatial Scales-- Environmental Release Based on: Uniform System for the Evaluation of Substances v.4.0, 2002

  9. RELEASE FATE/TRANSPORT CONCENTRATION ACTIVITY EXPOSURE Release Transport Reaction Market Share Population Location Frequency Timing Product Use Scenarios PRODUCT 1 CONSUMERUSE IndoorAir PRODUCT 2 OutdoorAir PRODUCT 3 HumanExposure SurfaceDust PRODUCT 4 PRODUCT 5 Soil A C T I V I T I E S PRODUCT 6 PRODUCT 7 Water PRODUCT 8 Food PRODUCT … Disposal PRODUCT n

  10. Near- and Mid Field Exposures Cleaning, Personal Care, Hobby products NEAR-FIELD

  11. Product Disposal RELEASE FATE / TRANSPORT CONCENTRATION ACTIVITY EXPOSURE Water ProductDisposal EnvironmentalRelease Air HumanExposure A C T I V I T I E S Land Food

  12. PRODUCT 1 PRODUCT 2 PRODUCT 3 PRODUCT 4 PRODUCT 5 Market Share Population PRODUCT 6 Location Frequency PRODUCT 7 Timing PRODUCT 8 PRODUCT … PRODUCT n RELEASE FATE / TRANSPORT CONCENTRATION ACTIVITY EXPOSURE WorkplaceExposure Chemical Manufacture Water FRAMEWORK Food EnvironmentalRelease Chemical Transportation HumanExposure Land A C T I V I T I E S Air Production/Formulation EnvironmentalDisposal Incineration Intermediates Recycling SewageTreatment Chemical ProductUse Degradates IndoorAir OutdoorAir Release Transport HumanExposure SurfaceDust Reaction Soil A C T I V I T I E S Water Food Disposal Water HumanExposure Product Disposal EnvironmentalRelease A C T I V I T I E S Air Land Food

  13. Summary • Framework is critical • Understand what we need, what we have, and identify gaps • Provides a basis for communications • Provides a systematic approach for developing and evaluating tools, databases, and protocols • Supports screening and higher tier models • Allows an evaluation of trade off – energy, land use, etc.

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