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20% O 2. Relative cell number. 1 % O 2. Days. Supplementary Fig. 1. A. B. C. Tumor Volume (mm 3 ). *. Vascular density. 25. 20. D. E. 15. 10. 5. Depth of invasion ( m m). 0. active caspase-3 positive cells / mm 2. Ki-67 positive cells (%). shNT. Parent. shCBS#07.

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Days

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  1. 20% O2 Relative cell number 1% O2 Days Supplementary Fig. 1

  2. A B C Tumor Volume (mm3) * Vascular density 25 20 D E 15 10 5 Depth of invasion (mm) 0 active caspase-3 positive cells / mm2 Ki-67 positive cells (%) shNT Parent shCBS#07 Supplementary Fig. 2

  3. HIF-2a mRNA levels Supplementary Fig. 3

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