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20% O2 Relative cell number 1% O2 Days Supplementary Fig. 1
A B C Tumor Volume (mm3) * Vascular density 25 20 D E 15 10 5 Depth of invasion (mm) 0 active caspase-3 positive cells / mm2 Ki-67 positive cells (%) shNT Parent shCBS#07 Supplementary Fig. 2
HIF-2a mRNA levels Supplementary Fig. 3