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Impact of miR-138 on FOSL1 mRNA Expression in UM1 and 1386Ln Cells

This study investigates the role of miR-138 in regulating FOSL1 mRNA levels. UM1 and 1386Ln cells were treated with either a miR-138 mimic or a control mimic, while 686Tu cells received anti-miR-138 LNA or negative control LNA. The expression levels of FOSL1 were assessed using quantitative RT-PCR across at least three independent experiments to ensure reliability. Results indicated a significant effect of miR-138 on FOSL1 expression, with p-values less than 0.05, highlighting miR-138's potential as a regulatory molecule.

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Impact of miR-138 on FOSL1 mRNA Expression in UM1 and 1386Ln Cells

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  1. * * * 1 0.5 - + 0 - + - - - - Relative FOSL1 mRNA level - - - + miR-138 mimic control mimic anti-miR-138 LNA control LNA - - - + - - - + - - - + UM1 1386Ln 686Tu Supplementary Figure 1: The effect of miR-138 on FOSL1 expression at mRNA level. UM1 and 1386Ln cells were treated with either miR-138 mimic or control mimic, and 686Tu cells were treated with either anti-miR-138 LNA or negative control LNA. The expression of FOSL1 was examined by quantitative RT-PCR. Data represent at least 3 independent experiments with similar results. *: p < 0.05.

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