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1. College of the Canyons, Department of Biological Sciences Presents:History of Microbiology or How a Science Develops
2. 1590 Janssen
Principle of the microscope
3. 1665 Hooke
Cell Biology
4. 1680 Leeuwenhoek
Dutch merchant
5. 1680 Leeuwenhoek
Described animalcules
6. 1680 Redi
Attacked the concept of abiogenesis (macro)
7. 1750 Needham
Set back the concept of omne vivum ex vivo
8. 1774 Spallanzani
vital force
9. 1776 Spallanzani
Hermetically sealed flasks excluded oxygen
10. 1836 Schulze
Use of acids & bases
11. 1837 Schwann
Use of heat
12. 1850-1875 Pasteur
A chemist
13. 1850-1875 Pasteur
Disproved abiogenesis (micro)
14. 1850-1875 Pasteur
Proved microorganisms as causative agents in putrefaction and fermentation
15. 1850 - 1875 Koch
Established isolation techniques
16. 1850 - 1875 Koch
Proved the nature of a specific organism for a specific disease (Henles postulates)
17. 1850 - 1875 Koch
Proved germ theory
18. 1875-1915 Golden Age continues
19. 1875-1915 Golden Age continues
Winogradsky
Soil
20. 1875-1915 Golden Age continues
Soxhlet
Dairy
21. 1875-1915 Golden Age continues
Burrill
Plant pathology
22. 1875-1915 Golden Age continues
Iwanoski
Virology
23. 1928 Fleming
Discovered Penicillin
24. 1928 Griffith
Transformation
25. 1932 Domagk
Sulfa drugs
26. 1936 Stanley
Crystallized a virus
27. 1938 Molecular Biology
28. 1942 Beadle & Tatum
One gene, one enzyme
29. 1943 Electron Microscope
30. 1944 Avery
Molecular genetics
31. 1944 Avery
DNA heredity
32. 1945 Chain & Florey
Discovered effects & use of penicillin
33. 1946 Lederberg
Bacterial genetics
34. 1950 Enders
Growth of viruses
35. 1953 The War of the Worlds
36. 1955 Salk
Polio vaccine
37. 1955 Watson & Crick
Double helix(DNA structure)
38. 1960 Porter
Immuno-chemistry
39. 1960 Porter
Elucidation of antibody molecules
40. 1968 Niremberg
Synthesized a polypeptide
41. 1970 Khorana
Synthesized a gene
42. 1970 Functional aspects of a recombinant gene
43. 1970 Isolation of restriction endonucleases
44. 1972 Berg
Recombinant DNA
45. 1975 Baltimore
Identification of reverse transcriptase
46. 1976 Sanger
Rapid sequencing of bases in synthetic DNA production
47. 1977 Gilbert
Synthesis of useful non-bacterial proteins (insulin & interferon) by bacteria
48. 1980 AIDS
Acquired ImmuneDeficiency Syndrome
49. 1983 Eli Lily Co.
Marketing of human insulin based on recombinant DNA, biotechnology market
50. 1987 Tonegawa
Genetic principle of antibody diversity
51. 1989 Bishop & Varmus
Genetic basis of cancer
52. 1990 Anderson & Blaese (NIH)
First approved gene therapy experiment
53. 1996 Ho
Cocktail therapy for AIDS
54. 1997-1999 Attack of the Clones
55. 21st Century Human Genome Project
Results
Genomics
Proteomics