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Epidemiology of Chlamydia in the United States

Epidemiology of Chlamydia in the United States. Debra J. Mosure, Ph.D. Division of STD Prevention Centers for Disease Control and Prevention March 8, 2004. Genital Chlamydia trachomatis Infections. Tremendous burden of infection Estimated annual incidence in 2000: 2.8 million

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Epidemiology of Chlamydia in the United States

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  1. Epidemiology of Chlamydia in the United States Debra J. Mosure, Ph.D. Division of STD Prevention Centers for Disease Control and Prevention March 8, 2004

  2. Genital Chlamydia trachomatis Infections • Tremendous burden of infection Estimated annual incidence in 2000: 2.8 million Estimated annual incidence in 15-24 year olds in 2000 : 1.5 million Estimate annual medical cost: $374.6 million • Over 70% of infections asymptomatic • Major cause of reproductive health consequences in women

  3. Devastating Consequences infertility chlamydia 20% 20-50% ectopic pregnancy 9% pelvic inflammatory disease 10-40% gonorrhea 18% chronic pelvic pain • Infectious complications • Neonatal pneumonia or eye infections in 60-70% of infants born to untreated mothers • At least 2-5 fold increased risk of HIV infection

  4. Two Components of Chlamydia Surveillance Case Reporting Prevalence Monitoring

  5. Chlamydia — Number of states that require reporting of Chlamydia trachomatis infections: United States, 1987–2002

  6. Chlamydia — Rates by sex: United States, 1984–2002

  7. Chlamydia — Age- and sex-specific rates: United States, 2002

  8. Chlamydia Surveillance Systems Chlamydia Prevalence Monitoring Case Reporting Regional Infertility Prevention Projects Jail Prevalence Monitoring Project

  9. Chlamydia — Trends in positivity among 15-44 year old women tested in family planning clinics by HHS regions, 1988–2002 Note: Trends adjusted for changes in laboratory test method and associated increases in test sensitivity. No data on laboratory test method available for Region VII in 1995 and Regions IV and V in 1996.

  10. Chlamydia — Positivity among women tested in family planning clinics by age group: Region X, 1988–2002 Note: Women who met screening criteria were tested. Trends not adjusted for changes in laboratory test method and associated increases in test sensitivity in 1994 and 1999–2002.

  11. Chlamydia — Positivity among women tested in family planning clinics by race and ethnicity: Region X, 1988–2002 Note: Women who met screening criteria were tested. Trends not adjusted for changes in laboratory test method and associated increases in test sensitivity in 1994, and 1999–2002.

  12. Chlamydia — Positivity among 15-30 year old women tested in Indian Health Service Clinics by IHS areas, 2002 *IHS areas not reporting chlamydia positivity data during 2002. SOURCE: Indian Health Service

  13. Chlamydia — Positivity in women entering juvenile and adult corrections facilities, 2002 Note: The median positivity is presented from facilities reporting >100 test results. California, Pennsylvania, Massachusetts, and Texas submitted data from more than one adult corrections facility. Arizona, California, Massachusetts, Texas and Washington submitted data from more than one juvenile corrections facility.

  14. Chlamydia — Positivity in men entering juvenile and adult corrections facilities, 2002 Note: The median positivity is presented from facilities reporting >100 test results. Massachusetts submitted data from more than one adult corrections facility. Arizona, California, Illinois, Maryland, Massachusetts, Texas, Utah, Washington and Wisconsin submitted data from more than one juvenile corrections facility.

  15. Chlamydia Surveillance “True” Prevalence

  16. Chlamydia — Prevalence among 16-24 year-old women entering the National Job Training Program by state of residence, 2002 *Fewer than 100 women residing in these states and entering the National Job Training Program were screened for chlamydia in 2002. SOURCE: U.S. Department of Labor

  17. Chlamydia — Prevalence among women and men by age group (NHANES), 1999-2000 Females Males

  18. Sexually Transmitted Diseases Laboratory Test Survey • Collaboration between the Association of Public Health Laboratories and the Centers for Disease Control and Prevention • To collect information about the volume and type of testing for STDs in the U.S.

  19. Laboratory Survey ResultsType of Chlamydia Tests in 2000 Reference: Dicker LW, Mosure DJ, Steece R, Stone K. Laboratory tests used in U.S. Public Health Laboratories for Sexually Transmitted Diseases, 2000. Sexually Transmitted Diseases 2004 (in press).

  20. Manufacturer* Survey Results Chlamydia Tests Sold in 2001 *Abbott Laboratories, Becton, Dickinson and Company, Gen-Probe, Incorporated, Roche Diagnostics Corporation, and Wampole Laboratories

  21. Chlamydia Screening Recommendations Centers for Disease Control and U.S. Preventive Services Task Force recommend screening • all sexually active females aged 15-19 years at least annually • all sexually active females aged 20-25 years annually • sexually active females > 25 years with risk factors (e.g., new sex partner or multiple sex partners)

  22. What is HEDIS? Health Plan Employer Data and Information Set • Performance measurement • to assess quality in managed care • organizations (MCO’s) • 90% of MCO’s report on HEDIS • measures HEDIS Report Card

  23. HEDIS Chlamydia* Screening Rates 2002 Medicaid Private * Chlamydia measure: number eligible women receiving chlamydia screening number sexually active women, aged 15 through 25

  24. Chlamydia Screening Coverage for 15-19 Year Old Women by U.S. Census Region*, 2000 % Coverage 90% Credibility Interval • Estimates exclude 4 states with >100% coverage • Reference: Levine WE, Dicker LW, Devine O, Mosure DJ. Indirect estimation of chlamydia screening coverage using public health surveillance data . American Journal of Epidemiology (in press).

  25. Summary • Two components of chlamydia surveillance: case reporting and prevalence monitoring • Increase in case reports in men and women from 1984 to 2002 • Limitations of case reports to monitor trends in chlamydia: reporting laws and amount of screening • Prevalence has declined in areas of the U.S. where large scale screening programs have been implemented • Prevalence remains high among persons at risk: women < 20 years and persons entering correctional facilities

  26. Summary • Estimated 24 million chlamydia tests sold in 2001 70% were non-NAATs, 77% sold to private labs • Most common types of chlamydia performed in 2000 were DNA probes • Managed care plans participating in HEDIS indicate that < 25% of private insured and <40% of women with Medicaid screened • 55%-66% of sexually active women 15-19 years of age in the U.S. were screened in 2000

  27. Chlamydia in the U.S.

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