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Primary HIV-Associated Neurologic Problems

HIV infection can lead to several neurologic problems, including neurocognitive disorders, dementia, peripheral neuropathy, myelopathy, and myopathy. These conditions significantly affect patients' quality of life. Research spanning from the pre-antiretroviral era to current HAART treatments has shown varying rates of neurologic impairment, highlighting the ongoing challenges in management. Understanding the epidemiology of these disorders is crucial for healthcare providers to tailor therapies that improve outcomes for individuals living with HIV.

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Primary HIV-Associated Neurologic Problems

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  1. Primary HIV-AssociatedNeurologic Problems • HIV-associated neurocognitive disorder and dementia • Peripheral neuropathy • Myelopathy • Myopathy

  2. Neurocognitive Impairment in the Pre-Antiretroviral, Pre-HAART, and HAART Eras Grant 1987 HNRC-500 1995 CHARTER 2008 87% 56% 54% 54% Patients With Neurologic Impairment (%) 52% 44% 44% 43% 31% 17% 9% 0% HIV Negative CDC-A CDC-B CDC-C HIV Positive

  3. HIV Neuropathogenesis:Post HAART Jones G, et al. Neurobiol Dis. 2006;21:1-17.

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