Comprehensive Models for PhzM and PhzS mRNA Interactions in PCA Dynamics
This work explores various models depicting the dynamics of PhzM and PhzS mRNA interactions within PCA systems. The study investigates scenarios with and without mRNA, focusing on feedback loops involving transcription factors (TFs) and their roles in constitutive expression. The models range from full systems incorporating mRNA to iterative models simplifying interactions while still capturing essential dynamics. This analysis enhances our understanding of regulatory mechanisms crucial for microbial communication and behavior.
Comprehensive Models for PhzM and PhzS mRNA Interactions in PCA Dynamics
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Presentation Transcript
Full model with mRNA – F1 tf mRNA_TF ka TF|S TF + S kd TF|S phzM phzS mRNA_PhzM mRNA_PhzS PhzM PhzS PCA MPCAB PYO
Full model without mRNA – F2 tf ka TF|S TF + S kd TF|S phzM phzS PhzM PhzS PCA MPCAB PYO
Positive Feedback loop with mRNA tf mRNA ka TF|S TF + S kd TF|S tf phzM phzS mRNA_PhzM mRNA_PhzS PhzM PhzS PCA MPCAB PYO
Positive feedback without mRNA – F3 tf ka TF|S TF + S kd TF|S tf phzM phzS PhzM PhzS PCA MPCAB PYO
Constitutive expression of PhzM without mRNA – F4 phzM tf PhzM PCA MPCAB PYO ka TF + S TF|S kd TF|S phzS PhzS
Constitutive expression of phzm with mRNA phzM tf mRNA_PhzM mRNA_TF PhzM PCA MPCAB PYO ka TF + S TF|S kd TF|S phzS mRNA_PhzS PhzS
Iteration 2 - Full model without MRNA and MPCAB - F5 tf ka TF|S TF + S kd TF|S phzM / phzS PhzM / PhzS PCA PYO
phzM Feedback loop for phzM - Karolois tf PhzM PCA MPCAB PYO ka TF + S TF|S kd phzM TF|S phzS PhzS
Iteration 2 – F6 tf ka TF|S TF + S kd TF|S tf phzM / phzS PhzM / PhzS PCA PYO
