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Cellular response to DNA damage

Cellular response to DNA damage. Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal of DNA damage Enzymatic photoreactivation

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Cellular response to DNA damage

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  1. Cellular response to DNA damage Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal of DNA damage Enzymatic photoreactivation Repair of O6-alkylguanine, O4- alkyltimidine Ligation of DNA strand breaks Excision of DNA damage Base Excision Repair Nucleotide Excision Repair Mismatch Repair Double strand breaks ligation Single strand annealing Recombinational Repair Non-Homologous End Joining

  2. La radiazione Solare può essere distinta in 3 componenti principali a seconda della lunghezza d’onda:ULTRAVIOLETTO (100-400 nanometri) 10% VISIBILE ( 400-750nm.) 45%INFRAROSSO (750-3000nm.) 45% Spettro della radiazione solare

  3. UV-induced damage

  4. UV-responsive photolyases

  5. Direct reversal (de-alkylating proteins)

  6. Base Excision Repair

  7. Nucleotide Excision Repair (E.coli)

  8. Nucleotide Excision Repair (Global Genome Repair -Humans)

  9. Nucleotide Excision Repair(Transcription Coupled -Humans)

  10. Common features of GGR & TCR

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