KELISEMA S.r.l.

1. Active Ingredients for the Cosmetic Industry KELISEMA S.r.l.

2. Kelisema in the worldOur major partners

3. Our products Vegetable Protein Derivatives Glusol Hydrolyzed Wheat Gluten Kelyamin Hydrolyzed Wheat Protein Gluplex series Native Wheat Protein - Surfactant Complexes Glusol 10K High Molecular Weight Hydrolyzed Wheat Protein Orysol Hydrolyzed Rice Protein Oryplex Native Rice Protein - Surfactant Complexes Maysol Hydrolyzed Corn Protein Kelisoy Hydrolyzed Soy Protein KeliPro Urtica Hydrolyzed Nettle Protein KeliPro Malva Hydrolyzed Mallow Protein

4. Our products Animal Protein Derivatives Kelimilk Hydrolyzed Milk Protein Keliwool Hydrolyzed Keratin Hydrolyzed Collagen Native Collagen 1% Soluble Collagen Desacol Desamidocollagen Collagen-Hyal Soluble Collagen and Sodium Hyaluronate Collagen LSS Soluble Collagen and Sodium Lauryl Sulfate Collagen IMZ Soluble Collagen and Sodium Cocoamphoacetate Collagen CTC Soluble Collagen and Cetrimonium Chloride Collagen CCK Soluble Collagen and Potassium Cocoate

5. Our products Specialties Thermal Heilmoor Heilmoor Clay Shea Butter Butyrospermum Parkii Cegaba Carboxyethyl-g-aminobutyric acid Sodium Hyaluronate Sodium Hyaluronate Kelifluo series Polyperfluoroethers-in-glycerin emulsions Vegetable Extracts Glycolic Extracts Hydroglycolic extracts Liposoluble extracts Propolis Aloe Gel

6. Protein Derivatives

7. Description High purity wheat protein hydrolysate obtained by gentle enzymatic digestion process. Optimum molecular weight and strategically placed amino acids for outstanding functional and technological benefits Available types Liquid 15% active matter, light colour and odour Liquid 35% active matter, light colour and odour Powder 95% active matter, preservative free Cosmetic Properties And Uses Improves skin/eye tolerability of surfactants Has hair conditioning and repairing effects Helps retaining moisture on hair and skin Thickens and stabilises foam in detergent formulation Glusol • Hydrolyzed Wheat GlutenGeneral Information

8. Technical Information Available Technical Data Sheet Safety Data Sheet Primary Skin Irritation Test Ocular Irritation Test Hair Substantivity Evaluation Surfactant Tolerability Improvement Evaluation Scavenging Activity Evaluation Foaming Properties Evaluation Glusol • Hydrolyzed Wheat GlutenGeneral Information

9. Surfactant Tolerability Improvement Evaluation Glusol reduces the transepidermal water loss caused by repeated use of irritant skin detergents Glusol • Hydrolyzed Wheat GlutenEffectiveness highlights

10. Scavenging Activity Evaluation The free radicals scavenging activity of Glusol is much higher than that of a common wheat protein hydrolysate Glusol • Hydrolyzed Wheat GlutenEffectiveness highlights

11. Description High purity wheat protein hydrolysate obtained by the action of a special enzyme pool, which yields a high level of free amino acids and small peptides Specifically featured for hair care and hair hygiene products Available types Liquid 20% active matter, light colour and odour Powder 95% active matter, preservative free Cosmetic Properties And Uses Repairs damaged hair keratin Imparts body and volume to the hair strand Helps retaining moisture on the hair surface Prevents hair damage in waving/colouring treatments Kelyamin • Hydrolyzed Wheat ProteinGeneral Information

12. Technical Information Available Technical Data Sheet Safety Data Sheet Primary Skin Irritation Test Hair Substantivity Evaluation Hair Hydrating Evaluation Hair Protection Evaluation Kelyamin • Hydrolyzed Wheat ProteinGeneral Information

13. Kelyamin • Hydrolyzed Wheat ProteinEffectiveness highlights Hair Substantivity Evaluation Hair substantivity from shampoo application. Comparison of Kelyamin with two commercial wheat protein hydrolysates

14. Kelyamin • Hydrolyzed Wheat ProteinEffectiveness highlights Hair Moisturisation Evaluation Kelyamin helps hair to absorb and retain moisture, contributing to the hair health and beauty

15. Native Wheat Proteins. Why use them in cosmetics ? They are cheap and easily available from renewable sources No hydrolysis process: their amino acids are not subject to degradation They have very high molecular weight They have very high hydrophobicity For these features, they display excellent skin protecting properties Problems They have very low water solubility They form a rubber-like matter in aqueous environment They are easily attacked by microorganisms Gluplex Series • Native Wheat Protein - Surfactant ComplexesBackground

16. Gluplex Series • Native Wheat Protein - Surfactant Complexes Mechanism and Aim of Protein-Surfactant Complexation Protein-Surfactant complexation… The chemical bonds generated between protein and surfactant molecules are weak but numerous. Main contributes are due to hydrophobic and ionic bonds The protein chains are unfolded without hydrolysys Primary and secondary structure of the proteins are unaffected The unfolding is reversible and there is no irreversible denaturation Proteins solubilisation is achieved Hydrophobicity of proteins is increased Native Wheat Proteins can be used in cosmetic formulations

17. Basic features Clear, low-coloured solutions Protein content 5% minimum Surfactant content 5-8% Ash 1-2% Full water miscibility Compatibility with surfactant solutions Major performances Surfactant irritancy reduction Improvement of foam properties of detergents Improvement of plasticity of syndets Substantivity to hair and skin Easy recovery in finished products Gluplex Series • Native Wheat Protein - Surfactant ComplexesGeneral Information

18. Description Aqueous solution of Native Wheat Proteins complexed with Sodium Laureth Sulfate. Available types Liquid 6% protein content Cosmetic Properties And Uses High molecular weight, high hydrophobic wheat proteins show excellent protection against surfactant irritancy; confer smoothness to the skin and prevent swelling of the hair strand on detersion Technical Information Available Technical Data Sheet Ocular Irritation Test Safety Data Sheet Surfactant Tolerability Evaluation Primary Skin Irritation Test Foaming Properties Evaluation Gluplex LES • Native Wheat Protein - Laureth Sulfate Complex General Information

19. Gluplex LES • Native Wheat Protein - Laureth Sulfate Complex Effectiveness highlights Foaming Properties Evaluation Small amounts of Native Wheat Proteins improve foaming and foam stability of Sodium Laureth Sulfate

20. Description Aqueous solution of Native Wheat Proteins complexed with Sodium Lauryl Sulfate. Available types Liquid 5% protein content Cosmetic Properties And Uses High molecular weight, high hydrophobic wheat proteins show excellent protection against surfactant irritancy; confer smoothness to the skin and prevent swelling of the hair strand on detersion Technical Information Available Technical Data Sheet Ocular Irritation Test Safety Data Sheet Surfactant Tolerability Evaluation Primary Skin Irritation Test Foaming Properties Evaluation Gluplex LS • Native Wheat Protein - Lauryl Sulfate Complex General Information

21. Gluplex LS • Native Wheat Protein - Lauryl Sulfate Complex Effectiveness highlights Surfactant Tolerability Improvement Evaluation Small amounts of Native Wheat Proteins improve the skin tolerability of detergent formulations

22. Description Aqueous solution of Native Wheat Proteins complexed with Sodium C14-16 Olefin Sulfonate. Available types Liquid 6% protein content Cosmetic Properties And Uses High molecular weight, high hydrophobic wheat proteins show excellent protection against surfactant irritancy; confer smoothness to the skin and prevent swelling of the hair strand on detersion Technical Information Available Technical Data Sheet Cytotoxicity Evaluation Safety Data Sheet Primary Skin Irritation Test Gluplex OS • Native Wheat Protein - Olefin Sulfonate Complex General Information

23. Description Aqueous solution of Native Wheat Proteins complexed with Potassium Cocoate. To be used in soap-based detergents. Available types Liquid 6% protein content Cosmetic Properties And Uses High molecular weight, high hydrophobic wheat proteins show excellent protection against surfactant irritancy; confer smoothness to the skin and prevent swelling of the hair strand on detersion Technical Information Available Technical Data Sheet Cytotoxicity Evaluation Safety Data Sheet Primary Skin Irritation Test Gluplex AC • Native Wheat Protein - Cocoate ComplexGeneral Information

24. Description High purity rice protein hydrolysate obtained by mild enzymatic hydrolysis of rice seed protein. Optimum average molecular weight of 3000 Daltons provides high hair/skin substantivity and product stability Available types Liquid 15% active matter, light colour and odour Powder 95% active matter, preservative free Cosmetic Properties And Uses Imparts body and volume to the hair strand Helps retaining moisture on the hair surface Improves skin/eye tolerability of surfactants Thickens and stabilises foam in detergent formulation Orysol • Hydrolyzed Rice ProteinGeneral Information

25. Technical Information Available Technical Data Sheet Safety Data Sheet Primary Skin Irritation Test Hair Substantivity Evaluation Foaming Properties Evaluation Orysol • Hydrolyzed Rice ProteinGeneral Information

26. Orysol • Hydrolyzed Rice ProteinEffectiveness Highlights Hair Substantivity Evaluation Orysol peptides are very well adsorbed on normal and damaged hair from aqueous solutions at mild exposition conditions (30°C, 15 minutes)

27. Description High purity corn protein hydrolysate obtained by the action of a special enzyme pool, which yields a high level of free amino acids (especially leucine, proline and sulphur-containing AA) and small peptides Available types Liquid 20% active matter, light colour and odour Powder 95% active matter, preservative free Cosmetic Properties And Uses Imparts body and volume to the hair strand Helps retaining moisture on the hair surface Thickens and stabilises foam in detergent formulation Maysol • Hydrolyzed Corn ProteinGeneral Information

28. Technical Information Available Technical Data Sheet Safety Data Sheet Primary Skin Irritation Test Hair Substantivity Evaluation Foaming Properties Evaluation Maysol • Hydrolyzed Corn ProteinGeneral Information

29. Maysol • Hydrolyzed Corn ProteinEffectiveness Highlights Hair Substantivity Evaluation Maysol peptides are very well adsorbed on normal and damaged hair from aqueous solutions at mild exposition conditions (30°C, 15 minutes)

30. Description High purity soy protein hydrolysate obtained by mild enzymatic hydrolysis of soy bean protein. Optimum average molecular weight of 2000 Daltons provides high hair/skin substantivity and product stability Available types Liquid 20% active matter, light colour and odour Liquid 40% active matter, light colour and odour Powder 95% active matter, preservative free Cosmetic Properties And Uses Helps retaining moisture on the hair surface Improves skin/eye tolerability of surfactants Thickens and stabilises foam in detergent formulation Kelisoy • Hydrolyzed Soy ProteinGeneral Information

31. Technical Information Available Technical Data Sheet Safety Data Sheet Primary Skin Irritation Test Foaming Properties Evaluation Kelisoy • Hydrolyzed Soy ProteinGeneral Information

32. Kelisoy • Hydrolyzed Soy ProteinEffectiveness Highlights Foaming Properties Evaluation Small amounts of Kelisoy improve foaming and foam stability of common anionic and amphoteric surfactants

33. Description An innovative selective extract from the leaves of Urtica dioica (common nettle). Contains the concentrated protein fraction, enzymatically hydrolyzed, with free amino acids. Dedicated to hair care cosmetics, where hair and scalp proteinisation is requested Available types Liquid 10% active matter Powder 95% active matter, preservative free Cosmetic Properties And Uses Repairs damaged hair keratin Imparts body and volume to the hair strand Helps retaining moisture on the hair surface KeliPro URTICA • Hydrolyzed Nettle ProteinGeneral Information

34. Description An innovative selective extract from the leaves of Malva sylvestris (mallow). Contains the concentrated protein fraction, enzymatically hydrolyzed, with free amino acids. Dedicated to skin care cosmetics and cleansing products, where proteinisation and moisturisation is requested Available types Liquid 10% active matter Powder 95% active matter, preservative free Cosmetic Properties And Uses Skin conditioner and film-forming agent with moisturising, soothening and protecting effects Improves skin tolerability of surfactants KeliPro MALVA • Hydrolyzed Mallow ProteinGeneral Information

35. Description Partial protein hydrolysate obtained by mild enzymatic hydrolysis of food-grade milk casein. About 20% of protein content is made of free amino acids Specifically featured for skin care and skin hygiene products Available types Liquid 15% active matter, light colour and odour Powder 95% active matter, preservative free Cosmetic Properties And Uses Helps retaining moisture on the skin surface Reduces the transepidermal water loss Improves skin/eye tolerability of surfactants Thickens and stabilises foam in detergent formulation Has a significant scavenging activity on free radicals Kelimilk • Hydrolyzed Milk ProteinGeneral Information

36. Technical Information Available Technical Data Sheet Safety Data Sheet Primary Skin Irritation Test Skin Hydration Evaluation Scavenging Activity Evaluation Kelimilk • Hydrolyzed Milk ProteinGeneral Information

37. Kelimilk • Hydrolyzed Milk ProteinEffectiveness Highlights Short Term Effects on the Hydration Parameters of the Skin Kelimilk produces a small increase of hydration, and a significant short-term reduction of the transepidermal water loss

38. Kelimilk • Hydrolyzed Milk ProteinEffectiveness Highlights Scavenging Activity Evaluation The free radicals scavenging activity of Kelimilk is much higher than that of a common milk protein hydrolysate

39. Description Partial protein hydrolysate obtained by mild enzymatic hydrolysis of virgin Merino wool, with food-grade proteases at low temperature and neutral pH. Optimum average molecular weight of 3000 Daltons provides high hair substantivity Specifically featured for hair care and hair hygiene products Available types Liquid 20% active matter, light colour and odour Powder 95% active matter, preservative free Cosmetic Properties And Uses Repairs damaged hair keratin Imparts body and volume to the hair strand Helps retaining moisture on the hair surface Prevents hair damage in waving/colouring treatments Keliwool • Hydrolyzed KeratinGeneral Information

40. Technical Information Available Technical Data Sheet Safety Data Sheet Primary Skin Irritation Test Hair Substantivity Evaluation Foaming Properties Evaluation Keliwool • Hydrolyzed KeratinGeneral Information

41. Keliwool • Hydrolyzed KeratinEffectiveness highlights Hair Substantivity Evaluation Keliwool peptides are very well adsorbed on normal and damaged hair from aqueous solutions at mild exposition conditions (30°C, 15 minutes)

42. Specialties

43. Description Natural peloid found in millennial deposits located at 800-1000 m above sea level in Lower Austria, formed by decomposition and slow biological maturation of plants. It is manually extracted and prepared in place without addition of chemical substances Available types The fibrous and gelatinous dark-brown paste as found in nature Cosmetic Properties And Uses The Thermal Helimoor Clay contains a variety of useful cosmetic substances: humic acids, phytosterols, tritrepenes, phospholipids, amino acids and a rich mineral fraction It can be used in face and body masks, bath products and creams for its revitalising, soothening and refreshing properties Thermal Heilmoor Clay • Thermal HeilmoorGeneral Information

44. Description Natural fat obtained by cold pressing the shea nuts and refined without the use of solvents, according to the best Italian olive oil tradition The chemical-physical and organoleptic characteristics of Shea Butter reflect the 100% natural standard quality. Tests have demonstrated its major activity releasing active substances in comparison with official ointments Available types The natural white to yellowish fatty fraction of shea nuts Cosmetic Properties And Uses For all skin-protecting products, sun products and for the treatment of skin dryness an ageing Shea Butter • Butyrospermum ParkiiGeneral Information

45. Description It is produced by controlled fermentation of selected bacterial strains. Its molecular weight is close to the analogous product obtained by extraction from cockscomb (mean value of 1.600.000 Daltons) Available types Liquid 1% active matter Powder 95% active matter Cosmetic Properties And Uses Hyaluronic acid (and its sodium salt) is known for its ability to reversibly bind a large amount of water molecules. On the skin surface it forms a highly hydrated, protecting layer that can maintain moisture for long, since the polymer is not absorbed into the skin The visco-elastic properties of the hydrated film confer a characteristic smoothness and reduce skin dryness and roughness Sodium Hyaluronate BioGeneral Information

46. Description Cegaba is a synthesised amino acid, naturally found in the cerebral tissue of mammalians, especially in the cerebrospinal liquid. This molecule is involved in the biosynthetic pathways that promote cell growth and cells proliferation Available types Liquid 2% active matter Liquid 10% active matter Powder 99% active matter Cosmetic Properties And Uses In vivo application of Cegaba has showed a significant increase of the proliferation rate of fibroblasts and the production of collagen fibres in the skin. A reduction of the hair loss rate has also been observed Cegaba • Carboxyethyl-g-aminobutyric acidGeneral Information

47. Description A range of anhydrous emulsions of cosmetic grade polyperfluoroethers in glycerine. An advantageous and practical tool for incorporating polyperfluoroethers in aqueous and anhydrous cosmetic formulation Available types Kelifluo 1500 10% and 25% Kelifluo 3200 10% and 25% Kelifluo 6250 10% and 25% Cosmetic Properties And Uses Emulsions, oils, gels, detergents, powders and a variety of cosmetic formulations can take advantage of the unique skin and hair protecting/hydrating properties of the Polyperfluoroethers contained in Kelifluo The Kelifluo predispersions can be used for the formulation of aqueous and anhydrous cosmetic systems Kelifluo Series • Predispersed Polyperfluoroethers EmulsionsGeneral Information

48. Via Urago, 13/B I-22038 Tavernerio – Como Tel. +39 031 427746 Fax +39 031 427745 www.kelisema.it office@kelisema.it Thanks you for your kind attention ! KELISEMA S.r.l.