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Investigation of eIF4G Interaction with HAV: Insights from 3ABC and 3C Mutants

This study focuses on the interaction dynamics between the eukaryotic translation initiation factor 4 gamma (eIF4G) and Hepatitis A Virus (HAV) proteins, particularly the 3C and 3ABC mutants. Using both in vitro and in vivo assays, we explore the molecular mechanisms underlying viral manipulation of the host translation machinery. Key data include quantitative assessments of protein interactions and their impact on translation efficiency, alongside graphical representations (Fig. S1, S2, S3) for clarity. Results suggest significant functional implications in viral replication.

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Investigation of eIF4G Interaction with HAV: Insights from 3ABC and 3C Mutants

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  1. 3ABCwt CVB 3C HAV inf 3ABCm 3ABCµ mock mock 3Cµ 3C A B kDa eIF4G 149 60 ΔeIF4G 1 2 3 4 5 6 7 8 9 Fig. 1S

  2. S10 S200 P200 • kDa • 97 • 52 • - 33 + - + - + - HAV 3C PABP 1 2 3 4 5 6 Fig. 2S

  3. Fig. 3S

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