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New Pharmacotherapies for Assisting Smokers in Their Cessation Efforts

Explore new pharmacotherapies like Varenicline, Rimonabant, and Nicotine Vaccine for smoking cessation. These innovative treatments offer hope to smokers seeking effective ways to quit and prevent relapse.

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New Pharmacotherapies for Assisting Smokers in Their Cessation Efforts

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  1. New Pharmacotherapies for Assisting Smokers in Their Cessation Efforts Frank Vocci, Ph.D. Director, DPMCDA December 7, 2005

  2. Varenicline • Partial agonist at the 4ß2 nicotine receptor • Partial agonists have some effects like nicotine but can also act like antagonists • A dual mechanism of action is proposed: • Partial nicotine-like effects • Nicotine blockade from cigarette smoking

  3. Varenicline

  4. Varenicline Phase II Trials- Tonstad study

  5. Rimonabant • CB1 inverse agonist/ antagonist • Stratus-US Study ( unpublished) • Quit rates in the 20 mg group were double that of placebo • Weight gain in the 20 mg group was 0.4 kg for 12 weeks versus 3.6 kg for placebo • The 20 mg group also had attenuated weight gain 1.5 kg versus and additional 3.5 kg for placebo

  6. Rimonabant • May be sought after by smokers who want to quit but don’t want to gain weight • Could be tested with other therapies, especially NRT for additive effects • Has other metabolic effects which can independently reduce cardiovascular disease risk

  7. Nicotine Vaccine • Being produced by three companies • Potential indications: • Aid to cessation • Prevention of relapse • And prevention of smoking

  8. Nicotine Vaccine

  9. Nicotine Vaccine

  10. Nicotine Vaccine Blocks Nicotine Self-Administration

  11. New Therapies • Offer new prospects for smokers looking for an assist to quit smoking • Each may have distinct advantages • The vaccine may be useful for relapse prevention • Other medications are also being developed

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