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Comprehensive Overview of Hepatitis B: Prevalence, Screening, and Management Strategies

This crash course on Hepatitis B by Yu-Ming Chang provides essential insights into the prevalence of chronic HBV infection among adults aged 19-49 as of 2005. It highlights key screening recommendations for high-risk populations, including Africans over 20 years old and Asian individuals over 40 or 50 years. The course emphasizes the simplicity of treatment despite the complexities of HBV infection and provides crucial take-home points on managing HBV, including the need for regular screenings for hepatocellular carcinoma (HCC) and the importance of vaccination against co-infections.

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Comprehensive Overview of Hepatitis B: Prevalence, Screening, and Management Strategies

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  1. Hepatitis B: A Crash Course Yu-Ming Chang October 21, 2014

  2. Prevalence of Chronic HBV Infection Age 19-49 in 2005 http://wwwnc.cdc.gov/travel/yellowbook/2014/chapter-3-infectious-diseases-related-to-travel/hepatitis-b

  3. HCC Screening • Africans over 20 years of age • Asian men over 40 years • Asian women over 50 years • Any carrier over 40 years with persistent or intermittent ALT elevation and/or high HBV DNA level >2,000 IU/mL • Cirrhosis • Family history of HCC

  4. Take Home Points • HBV infection can be complicated but treatment is simple • HBV-induced transaminitis can wax/wane • Persistently normal ALT with HBS antigen positivity do not require treatment • Chronic HBV: get CMP, INR, CBC, HBV DNA before referring to hepatology • Don’t forget co-infections: HCV, HDV, HIV • Don’t forget vaccination: HAV, flu, Pneumococcal • Don’t forget HCC screen in non-cirrhotic patients

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