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3D (Paritaprevir-Ritonavir-Ombitasvir + Dasabuvir) + RBV in GT1 TURQUOISE-II

Phase 3. Compensated Cirrhosis. Treatment Naïve and Treatment Experienced. 3D (Paritaprevir-Ritonavir-Ombitasvir + Dasabuvir) + RBV in GT1 TURQUOISE-II. Poordad F, et al. N Engl J Med. 2014;370:1973-82. 3D + Ribavirin in GT1 and Compensated Cirrhosis TURQUOISE- II: Study Design.

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3D (Paritaprevir-Ritonavir-Ombitasvir + Dasabuvir) + RBV in GT1 TURQUOISE-II

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  1. Phase 3 Compensated Cirrhosis Treatment Naïve and Treatment Experienced 3D (Paritaprevir-Ritonavir-Ombitasvir + Dasabuvir) + RBV in GT1 TURQUOISE-II Poordad F, et al. N Engl J Med. 2014;370:1973-82.

  2. 3D + Ribavirin in GT1 and Compensated CirrhosisTURQUOISE-II: Study Design Source: Poordad F, et al. N Engl J Med. 2014;370:1973-82.

  3. 3D + Ribavirin in GT1 and Compensated CirrhosisTURQUOISE-II: Regimens 0 12 24 36 Week 3D + Ribavirin Group AN = 208 SVR12 3D + Ribavirin Group BN = 172 SVR12 3D = Paritaprevir-ritonavir-Ombitasvir + Dasabuvir Drug Dosing3D = Paritaprevir-ritonavir-Ombitasvir (150/100/25 mg once daily)+ Dasabuvir: 250 mg twice dailyRibavirin (RBV): weight-based and divided bid (1000 mg/day if < 75kg or 1200 mg/day if ≥ 75kg) Source: Poordad F, et al. N Engl J Med. 2014;370:1973-82.

  4. 3D + Ribavirin in GT1 and Compensated CirrhosisTURQUOISE-II: Results TURQUOISE II: SVR12 by Genotype 1 Subtype 191/208 165/172 124/140 114/121 67/68 50/51 Source: Poordad F, et al. N Engl J Med. 2014;370:1973-82.

  5. 3D + Ribavirin in GT1 and Compensated CirrhosisTURQUOISE-II: Results TURQUOISE II: SVR12 Based on Prior Treatment 81/86 70/74 28/29 23/23 17/18 13/13 65/75 59/62 Source: PoordadF, et al. N Engl J Med. 2014;370:1973-82.

  6. 3D + Ribavirin in GT1 and Compensated CirrhosisTURQUOISE-II: Results for GT1a TURQUOISE II: Genotype 1a SVR12 Based on Prior Treatment 59/64 52/56 14/15 13/13 11/11 10/10 40/50 39/42 Source: PoordadF, et al. N Engl J Med. 2014;370:1973-82.

  7. 3D + Ribavirin in GT1 and Compensated CirrhosisTURQUOISE-II: Results for GT1b TURQUOISE II: Genotype 1b SVR12 Based on Prior Treatment 22/22 18/18 14/14 10/10 6/7 3/3 25/25 20/20 Source: PoordadF, et al. N Engl J Med. 2014;370:1973-82.

  8. 3D + Ribavirin in GT1 and Compensated CirrhosisTURQUOISE-II: Adverse Effects Source: PoordadF, et al. N Engl J Med. 2014;370:1973-82.

  9. 3D + Ribavirin in GT1 and Compensated CirrhosisTURQUOISE-II: Adverse Effects Source: PoordadF, et al. N Engl J Med. 2014;370:1973-82.

  10. 3D + Ribavirin in GT1 and Compensated CirrhosisTURQUOISE-II: Conclusions Source: Poordad F, et al. N Engl J Med. 2014;370:1973-82.

  11. This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects. Hepatitis C Onlinewww.hepatitisc.uw.edu Hepatitis Web Studyhttp://depts.washington.edu/hepstudy/ Funded by a grant from the Centers for Disease Control and Prevention.

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