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CTOS 12th Annual Meeting Venice, 2-4 November 2006

CTOS 12th Annual Meeting Venice, 2-4 November 2006 Myxoid/RC Liposarcoma: Prognostic Factors And Survival. Marco Fiore marco.fiore@istitutotumori.mi.it. Soft Tissue Sarcoma INT 1980-2005. 23%. N° pz. operated 3026 Liposarcoma 685 MFH/Pleomorphic sarcoma 389

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CTOS 12th Annual Meeting Venice, 2-4 November 2006

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  1. CTOS 12th Annual Meeting Venice, 2-4 November 2006 Myxoid/RC Liposarcoma: Prognostic Factors And Survival Marco Fiore marco.fiore@istitutotumori.mi.it

  2. Soft Tissue SarcomaINT 1980-2005 23% N° pz. operated 3026 Liposarcoma 685 MFH/Pleomorphic sarcoma 389 Leiomiosarcoma 372 DFSP 260 Aggressive Fibromatosis 240 Synovial Sarcoma 224 MPNST 222 Sarcoma NOS 143 Others 491

  3. 685 Liposarcoma INT 1980-2005 WD Liposarcoma 233 Dediff Liposarcoma 123 Myxoid Liposarcoma 202 Round cell Liposarcoma 66 Pleomorphic Liposarcoma 61 48%

  4. myxoid FUS/TLS-CHOP t(12;16)(q13;p11) (95%) FUS/TLS CHOP/DDIT3 round cell EWS EWS-CHOP t(12;22)(q13;q12) (5%) pleomorphic

  5. 329 Myxoid/RC Liposarcoma INT 1980-2005 75%

  6. 329 Myxoid/RC Liposarcoma INT 1980-2005 Median Age 49 yrs Male : Female 1 : 1 Median Size 8.5 cm Deep Site 84% Grade (FNCLCC) I 54% II 23% III 22%

  7. Prognosis depends on…

  8. the tumor

  9. Multivariate Analysis - DSS

  10. Size… STS high grade DFS <2,5 2,5-5 5-10 10-15 15-20 >20 cm Suit HD. J Clin Oncol 1988; 6: 854

  11. Site…

  12. Grading… OS grade 1 grade 2 grade 3

  13. Round cell component… RC >5% Antonescu CR, Clin Cancer Res 2001;7:3977

  14. 214 Primary Myxoid/RC LPS - DSSINT 1980-2005

  15. 214 Primary Myxoid/RC LPS - LRINT 1980-2005

  16. 214 Primary Myxoid/RC LPS - DMINT 1980-2005 p=.0018

  17. Pattern of Distant Mets 41% extra-pulmonary mets 26% lung mets 33% both 74% of metastatic patients had at least one extra-pulmonary mets

  18. 43% 49% 33%

  19. Time to Event (mos)

  20. Post-Event Median Survival (mos)

  21. Post-Event Median Survival (mos)

  22. the surgeon

  23. LR Intralesional 100% Marginal 60-80% Wide 10-30% Radical < 5% Enzinger and Weiss’sSOFT TISSUE TUMORS - 2001

  24. Multivariate Analysis - DSS

  25. Local recurrence has an independent effect on prognosis

  26. 115 Recurrent Myxoid/RC LPS - DSSINT 1980-2005

  27. 115 Recurrent Myxoid/RC LPS - LRINT 1980-2005

  28. 115 Recurrent Myxoid/RC LPS - DMINT 1980-2005

  29. … in conclusion

  30. Prognosis of myxoid/round cell liposarcoma is relatively good, if compared with other STS • Cut-off of 5% of RC component single out a group tumor with 81% 10-yrs DSS, which is actually in the range of intermediate grade STS • As expected, phase at presentation, tumor size and grade,and surgical margins are independent prognostic factors for survival • Pattern of metastases can affect survival

  31. … marco.fiore@istitutotumori.mi.it

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