1 / 9

Gene Mutation

Gene Mutation. *Mutation. Chromosome mutations/aberrations. Classification of Mutations. 1. Spontaneous vs. Induced Spontaneous mutation Induced mutation. 2. Gametic vs. Somatic Somatic mutation Gametic mutation. 3. Other categories. Gene Mutation.

paulos
Télécharger la présentation

Gene Mutation

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Gene Mutation *Mutation Chromosome mutations/aberrations Classification of Mutations 1. Spontaneous vs. Induced Spontaneous mutation Induced mutation 2. Gametic vs. Somatic Somatic mutation Gametic mutation 3. Other categories

  2. Gene Mutation How are mutations detected in humans? *Pedigree analysis *Cells cultured in vitro Analysis of enzyme activity, sequencing of proteins and DNA The molecular basis of mutation (Point mutations) 1. Base substitution transition transversion 2. Frame shift 3. Tautomeric shift 4. Base analogs 5. Chemical mutagens

  3. 2. UV light – thymine/thymine dimers Gene Mutation 3.Ionizing radiation The molecular basis of mutation (Structural damage) 1. “Missing bases” N-glycosidic bond – very weak and easily broken

  4. Genotype:IAIA, IAIO A A IBIB, IBIO IAIB IOIO B B B A A B A A A A A B A A B B B A B glycosyltransferase “H substance” 4 nucleotide differences glycosyltransferase B “H substance” X “H substance” Frame-shift=non-functional protein Gene Mutation Mutations in humans ABO Blood Types A A

  5. Gene Mutation DNA Repair 1. Photoreactivation *PRE – photoreactivation enzyme

  6. (BER) Gene Mutation 3. Excision repair DNA Repair 2. 3’ to 5’ exonuclease activity of DNA polymerases

  7. Gene Mutation 3. Excision repair

  8. Gene Mutation 4. Post-replication repair (recombination repair) recombined

  9. Gene Mutation 5. Inducible repair or SOS (prokaryotes) *”It’s better to be a mutant than be dead!”

More Related