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Insights into Immune Cell Activation and Angiogenesis in Rheumatoid Arthritis

Explore the intricate network of cytokines, growth factors, and adhesion molecules involved in T-cell activation and angiogenesis within the synovium of RA patients. Discover the impact of key regulators like IL-15, MIF, and IL-18 on effector T-cell function and resistance to apoptosis.

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Insights into Immune Cell Activation and Angiogenesis in Rheumatoid Arthritis

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  1. IL-15

  2. MIF MMP IL-18 T1,2 IFN-g IL-2 activation of T-cell, Φ, fibroblast in synovium of RA Angiogenesis VEGF, FGF, HGF IL-8, angipoietin-1 Stromal cell derived GF TNF, TGF (indirect) Angiostatic IL-12,IFN-a b g, PF4 Adhesion molecules ICAM-1,2 VAM-1 *b-integrin LAF-3 *P-selectin AMG : IL-15 human monoclonal Ab BMP MIF IL-15 IL-15 T-cell migration IL-15 TNF-a IL-1 IL-6 IL-7 IL-8 IL18 MIF angiopoietin-1 SDGF, FGF IgG IL-1 TNF-a GM-CSF IL-6 MIF IL-12 IL-18 IFN-g IL-2 IL-4 IL-6 IL-5 IL-17 MIF B proliferation & resist to apoptosis effector T-cells IL-15 IL-15 T K Tc NK-IFN-g CD40 ligand IL-15  TNF-a production by Φ -- contact dependent with CD 40L (CD154)

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