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IL-8, TGF- b IFN- g , IL-12A, IL-15, IP-10, CSF-1, MIP-3 b , MCP-1, MCP-2

A. TNFAIP3. PBMC. Pre-Sort. PBMC. Pre-Sort. IL-8. Granzyme K. Down-Regulated. TOSO. TGF b -1. a. Caspase-6. ENDO-G. DFF-A. NGF-R. CD-27. TIA-1. Caspase-8. NK-4. Lymphotoxin- b. Caspase-2 BCL-2. b. Lymphotoxin- a. TRAIL FAS. TNFSF13 Cathepsin W Granzyme B Perforin 1

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IL-8, TGF- b IFN- g , IL-12A, IL-15, IP-10, CSF-1, MIP-3 b , MCP-1, MCP-2

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  1. A TNFAIP3 PBMC Pre-Sort PBMC Pre-Sort IL-8 Granzyme K Down-Regulated TOSO TGFb-1 a Caspase-6 ENDO-G DFF-A NGF-R CD-27 TIA-1 Caspase-8 NK-4 Lymphotoxin-b Caspase-2 BCL-2 b Lymphotoxin-a TRAIL FAS TNFSF13 Cathepsin W Granzyme B Perforin 1 NKG-7 FLT-3L IFN-g CSF-1 TNF CCL2/MCP-1 CCL4/MIP-1b CCL3/MIP-1a BCL-2L1 Up-Regulated c Cathepsin L Cathepsin C TANK/NF-kB RIP NF-kBp105/p50 Calpain-1 Enolase-3 CXCL10/IP-10 IL-12-A d TRAF-5 SMAD-7 CCL23/MPIF-1/CKb8 Lymphokines IL-8, TGF-b IFN-g, IL-12A, IL-15, IP-10, CSF-1, MIP-3b, MCP-1, MCP-2 B ENDO-G NF-kBp100/p50B NF-kBp100/p50B NF-kBp105/p50 NF-kBp105/p50 Caspase -2 Caspse-8 DNA fragm BCL-2 BCL-2L1 Survival Caspase -6 DFFA rIL-2 Granules No-Stim Granzyme-K, TIA-1 NK-4, NKG-7, Perforin, Cathepsin-W, Granzyme-B FADD, TRADD, TRAF2 BCL-2 BCL-2L1 SCYE IL-15 NF-kBp100/p50B Survival FAS RIP TNFR-1 TNF-Family CD-27 TNF-a, FLT-3L, TRAIL, Lymphotoxin-a and –b, FAS NGFR, CD27

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