1 / 8

Impact of Bitumen Exposure on Nasal Inflammation Among Construction Workers

This study investigates the effects of bitumen exposure on nasal inflammation in construction workers, comparing workers with low and high exposure levels. The population consisted of 55 low exposure, 202 moderate, and 172 high exposure workers. Key analyses included neutrophil counts and cytokine levels (IL-8, IL-1β, TNF-α) in nasal lavage fluids pre and post-shift. Results revealed a small increase in neutrophils post-shift in high exposure groups, suggesting potential irritative effects distinct from allergies.

phuong
Télécharger la présentation

Impact of Bitumen Exposure on Nasal Inflammation Among Construction Workers

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Inflammation and nose

  2. Exposure group – Bitumen workers

  3. Reference group – outdoor construction workers

  4. Characteristics of the study population Low exposure Low exposure High exposure High exposure References References Exposed (total) Exposed (total) ?10 mg/m 10 mg/m >10 mg/m 10 mg/m 3 3 3 3 Attribute Attribute n=55 n=55 n=202 n=202 n=172 n=172 n=30 n=30 Exposure to fumes Exposure to fumes of and aerosols of 3.7 (0.1 3.7 (0.1 - - 41.7) 41.7) 3.0 (0.1 3.0 (0.1 - - 9.8) 9.8) 16.7 16.7 (10.2 (10.2 - - 41.7) 41.7) 3 3 bitumen (mg/m bitumen (mg/m ) ) - ? (median; range) (median; range) Age (years) Age (years) 37 (19 37 (19 - - 61) 61) 40 (17 40 (17 - - 63) 63) 40 (18 40 (18 - - 63) 63) 40.5 (17 40.5 (17 - - 52) 52) (median; range) (median; range) Current smoking Current smoking 23 ( 23 ( 41.8 41.8 %) %) 132 ( 132 ( 65.7 65.7 %) %) 113 (65.7%) 113 (65.7%) 20 (66.7%) 20 (66.7%) n (%) n (%) German nationality German nationality 48 ( 48 ( 87.3 87.3 %) %) 136 ( 136 ( 67.7 67.7 %) %) 121 (70.8%) 121 (70.8%) 15 (50.0%) 15 (50.0%) n (%) n (%) Duration of work in Duration of work in the current the current company (years) company (years) 6.5 (3 6.5 (3 - - 10) 10) 8 (3 8 (3 - - 14 14 ) ) 8 (3 8 (3 - - 14) 14) 6.5 (2 6.5 (2 - - 16) 16) (median; (median; interquartile range) interquartile range)

  5. Collection of nasal lavage fluids (NALF) Analysis: cellular and humoral parameters (e.g. IL-8, IL-1b, TNF-a, IL-6, NO, albumin)

  6. Neutrophils in NALF [%] – pre-/post-shift-comparison in the three exposure groups 60 55 50 45 p=0.023 p=0.010 40 Neutrophils in NALF [%] 35 p=0.020 p=0.0002 30 25 20 15 pre-shift post-shift reference group low exposure group high exposure group

  7. IL-8-determination in NALF [%] – pre-/post-shift-comparison in the three exposure groups 350 300 250 200 n.s. IL-8-concentration in NALF [pg/ml] n.s. 150 100 50 0 pre-shift post-shift reference group low exposure group high exposure group

  8. Conclusion NALF • Small increase of neutrophils after high airborne bitumen exposure during shift in nasal lavage • Although no direct comparison was made, irritative effects can possibly be differentiated from allergic effects

More Related