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D COOH PowerPoint Presentation

D COOH

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D COOH

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  1. ~12Kb ATG TGA B B B B B B B B B B B PGKneo PGKneo PGKneo P P P 12Kb 4.5Kb pA pA 8.5Kb 4.5Kb C A DCOOH/DCOOH DNH2/DNH2 PM/PM /DCOOH AD1 +/PM AD2 /DNH2 wt wt wt P P P P P P P Nkx2-1 P P P P 1 372 DNH2 372 159 DCOOH 1 221 D 1 372 PM /DCOOH DCOOH /DNH2 wt DNH2 wt B pr Wt Wt Mutant Transfected cells Thyroid DNH2 pA E - + - + 1 2 3 4 phosphatase DCOOH native dephosphorylated PM PM/PM lung WT lung