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Schmidt Lab Biomaterials Applications. Spinal Cord Repair Strategies (Zin). Soft Tissue Scaffolds (Richelle). Surgical Meshes (Sarah). Sources of Peripheral Nerve Injury. Cancer. Accidents. Congenital Defects. Photocrosslinked Hyaluronic Acid (GMHA). High Swelling HA Hydrogels.
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Schmidt Lab Biomaterials Applications Spinal Cord Repair Strategies (Zin) Soft Tissue Scaffolds (Richelle) Surgical Meshes (Sarah)
Sources of Peripheral Nerve Injury Cancer Accidents Congenital Defects
Photocrosslinked Hyaluronic Acid(GMHA) High Swelling HA Hydrogels Low Swelling HA Films Unswollen Saline Swollen Water Swollen Modulate: -Swelling -Degradation -Mechanical Properties
25 mm 12 mm Role of Physical vs. Chemical Cues Microchannels vs. Laminin Gomez, Chen, Schmidt (2007). J. R. Soc Interface. 4(13): 223-233. Physical cues are preferred over chemical cues for axon initiation (polarization) 70 % Physical Cues (microchannels) 30 % Chemical Cues (NGF or Laminin)
In Situ Crystallization: Dendritic Pores In Situ Crystallization: Dendritic Pores • Simple, inexpensive • No specialized equipment • No specialized skills • No organic solvents
Fibrillar, Porous Microstructure AFM SEM
Cell Guidance Zawko, Schmidt. (in press) Acta Biomaterialia.