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Immune System Review Book

Immune System Review Book. Fold a blank piece of paper into 8 rectangles, then cut them apart. Staple the pages together to make a booklet. Immune System Review Book. staples. The purpose of the book is to give you an overview/summary of the Immune system. Use it to help you study!.

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Immune System Review Book

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  1. Immune System Review Book Fold a blank piece of paper into 8 rectangles, then cut them apart. Staple the pages together to make a booklet. Immune System Review Book staples The purpose of the book is to give you an overview/summary of the Immune system. Use it to help you study!

  2. Cover of book: Immune System Review Book By: _________________

  3. The Three Lines of Defense: Surface Barriers Nonspecific Response Specific Response 1. Surface Barriers Inside cover (first pages) Left side right side Skin Tears Mucous Membranes Saliva Cough &Sneeze Friendly Bacteria Low pH Urine Diarrhea

  4. Non-specific Response Complement Proteins: Can interact with carb molecules on the surfaces of microorganisms Cascade Lysis Next pages Attack complexes insert into cell membrane and lyse microorganism (death) Reactions to make protein “membrane attack complexes”

  5. 2. Inflammatory Response— also non-specific Next Pages (I’m sorry I forgot these in class Wednesday! You can add them to the end of your booklet if it is too hard to insert them) d. Complement proteins attack bacteria a. Bacteria invade b. Tissue irritation causes mast cells to release histamine (shown here as red dots) e. Phagocytes engulf invaders c. Capillary walls become leaky. Fluid and complement proteins leak out. Swelling.

  6. Specific Response Antigen triggers formation of lymphocyte armies. T and B lymphocytes will specifically recognize FOREIGN antigens. T and B will divide repeatedly into effector and memory cells. Our own cells recognize each other. Cells have MHC markers designating “self.” Next pages antigen on surface of bacterial cell antigen on surface of virus

  7. 3. “T” Cell Mediated Response Next pages • T cell Receptor of Helper T cells recognize the specific MHC-antigen complex. Binding stimulates the macrophage to secrete interleukins. • Helper T releases interleukin 2. • Interleukin 2 stimulates cell division of effector cytotoxic T armies Antigen-MHC Complex a. Macrophages ingest virus particles. Virus antigens are not digested, ANTIGEN IS DISPLAYED IN MHC COMPLEX Effector cytotoxic T: What does cytotoxic T do?

  8. Antibody-mediated response (B cells) Antibody: Next pages Effector Cytotoxic T cells find body cells infected with the virus (virus antigen presented in antigen-MHC complex). They “touch kill” cells with perforins. antigen-binding sites antigen-MHC complex on infected body cell effector cytotoxic T cell touch-killed body cell

  9. B cell armies are made last pages 3. Antibody-mediated response B cell encounters unbound Antigen from bacteria. Receptors bind antigen. Antigen is displayed in MHC. Helper T binds to antigen-MHC.Interleukins are released. Interleukins trigger cell division: B cell armies are made. Effector B cells Make/secrete many antibodies Memory B cells are made, too

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