1 / 19

Specific immune system

Specific immune system. B-lymphocytes. Immune system diseases. Non specific immunity. Disease survival mechanisms. Physical & chemical barriers. Infectious Disease. Inflammatory. Transmission. Epidemiology. Non-specific Cellular response. Specific immunity. Public Health. Vaccination.

rayn
Télécharger la présentation

Specific immune system

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Specific immune system B-lymphocytes

  2. Immune system diseases Non specific immunity Disease survival mechanisms Physical & chemical barriers Infectious Disease Inflammatory Transmission Epidemiology Non-specific Cellular response Specific immunity Public Health Vaccination Immunological surveillance T cells B cells Clonal Selection theory Big picture

  3. Learning outcomes • Explain the role of lymphocytes, B cells in the immune system • Identify The need for immunological memory • Apply the Importance of primary and secondary responses

  4. Third line of defence • Specific (only acts on particular pathogen) • First immunological surveillance occurs to find/ discover pathogen • Then clonal selection needs to occur to find the corresponding lymphocyte to combat the pathogen

  5. B lymphocytes (b cells) • AN ANTIGEN IS A COMPLEX MOLECULE – RECOGNISABLE AS SELF OR FOREIGN/ NON-SELF • ANTIGEN TRIGGERS PRODUCTION OF ANTIBODIES • ANTIBODY IS A Y-SHAPED MOLECULE WITH A SPECIFIC RECEPTOR (BINDING SITE) • Lymphocytes respond specifically to antigens on foreign cells, cells infected by pathogens and toxins released by pathogens.

  6. Antigen - any agent capable of eliciting an immune response Isolated molecules Molecules on surface of cell or virus * A specific antibody molecule will be able to recognize a specific (epitope ) antigen Antibody binds to antigen Specific Immunity Antibody-Antigen Interaction

  7. B Cell activation B CELLS PLAY THREE IMPORTANT ROLES IN THE IMMUNE RESPONSE: • THEY PRODUCE ANTIBODIES IN RESPONSE TO SPECIFIC ANTIGENS • THEY PERFORM THE ROLE OF ANTIGEN-PRESENTING CELLS • THEY DEVELOP INTO MEMORY B CELLS.

  8. B CELL ANTIBODIES EACH B CELL CAN A PRODUCE A SPECIFIC ANTIBODY THAT CAN RECOGNISE A SPECIFIC ANTIGEN FROM A PATHOGEN OR TOXIN. THE ANTIBODY WILL BIND TO THE ANTIGEN, FORMING AN ANTIGEN–ANTIBODY COMPLEX. THE ANTIGEN–ANTIBODY COMPLEX HAS TWO MODES OF ACTION: • IT MAY INACTIVATE THE PATHOGEN/TOXIN (NEUTRALISATION), RENDERING IT SUSCEPTIBLE TO PHAGOCYTOSIS. • IT MAY STIMULATE A RESPONSE, RESULTING IN CELL LYSIS.

  9. Agglutination • Antibodies can cause microbes to stick together • This makes it easier for phagocytes to engulf them

  10. Inactivate • Antibodies can bind to pathogen • Causing them to become inactive / rendering them harmless

  11. Neutralisation • Some pathogens make us ill by producing toxins • Some antibodies work by neutralising these toxins

  12. Stimulate cell lysis • The binding of an antibody to the surface of a pathogen can set of a chain reaction with blood proteins, which... • ... causes the pathogen to swell up an burst.

  13. Need a little help from my friends .... • B cells can identify specific antigens and present them to T cells. • T cells can then destroy the pathogen.

  14. Signal 2 - T cell help B Th Th Y Y Y * T Helper Cells 1. T cell antigen receptor 2. Co-receptor (CD4) Signal 1antigen & antigenreceptor 3.CD40 Ligand

  15. SIGNAL More About T-Lymphocytes Help the humoral response by involvement in the maturation of B cells and by triggering the production of antibodies by B-cells Helper T-cells: Antigen B-cell Helper T-cell

  16. Clonal selection theory • The body has a large number of lymphocytes each with a single type of membrane receptor specific for one antigen. • When a receptor is activated by the binding of an antigen, the lymphocyte repeatedly divides resulting in a clonal population of lymphocytes. Cell division

  17. Summary slide Specific defences Immune surveillance • A range of white blood cells constantly circulate monitoring the tissues. • If tissues become damaged or invaded, cells release cytokines which increase blood flow resulting in specific white blood cells accumulating at the site of infection or tissue damage. • Recognition of self and non self through specific surface proteins (antigens) • Lymphocytes respond specifically to antigens on foreign cells, cells infected by pathogens and toxins released by pathogens.

  18. Summary slide specific defences B lymphocytes • Each B lymphocyte clone produces a specific antibody molecule that will recognise a specific antigen surface molecule on a pathogen or a toxin. • Antigen-antibody complexes may inactivate a pathogen or toxin or render it more susceptible to phagocytosis. • In other cases the antigen-antibody complex stimulates a response which results in cell lysis. • B lymphocytes activated by antigen presenting cells and T lymphocytes produce a clone of B lymphocytes that secrete antibodies into the lymph and blood where they make their way to the infected area.

  19. Summary slide Specific defences Immunological memory cells • Some T and B lymphocytes produced in response to antigens by clonal selection survive long term as memory cells. • A secondary exposure to the same antigen rapidly gives rise to a new clone of lymphocytes producing a rapid and greater immunological response.

More Related