Unlocking the Power of NHANES

1. Unlocking the Power of NHANES

2. Agenda • Introduction • Joshua Murphy, Vice President • Demonstration/Training • Dennis Wijnker, Senior Software Architect, VP of Technology • Question/Answer Session

3. Presenter Biography Dennis Wijnker Sr. Software Architect; VP, Technology Mr. Wijnker has more than 15 years of experience in Software Development, filling positions of technical and managerial leadership.  He has extensive experience building web-based and standalone platforms, primarily in the fields of Health Care and Life Sciences. Amongst others, Mr. Wijnker has developed a web-based fully configurable Electronic Data Capture platform for managing clinical trials that is still used today by many pharmaceutical companies and Clinical Research Organizations. He was also instrumental in integrating said platform with other technologies used in clinical trials. Prior to focusing on technology, Mr. Wijnker studied Bio-Pharmaceutical Sciences at Leiden University (Leiden, The Netherlands). At Doctor Evidence, Mr. Wijnker is responsible for software and systems architecture, product management as well as quality assurance. He has been involved in development of the company’s core software platform, led development for the NHANES Query tool and is currently focusing on a comprehensive and collaborative guideline development platform.

4. Doctor Evidence Core Solutions: LMS and EVP Our Solution is based on an integrated software platform that delivers web-based comparative effectiveness evidence. • Assess Comparative Effectiveness: Evaluate competing treatments by patient profile in a side-by-side view. • Analyze Clinical Literature Gaps: Identify holes in the published clinical evidence to plan future research or publications. • Replicate and Audit Systematic Reviews: Assess the strengths and weaknesses of the body of clinical evidence. Through an easy navigation system, users can create graphs, forest plots, and comparison reports with the click of a button. Our medically-compliant meta-analysis and pooling tools maximize the value of clinical data.

5. Doctor Evidence Platform Static References Doctor Evidence Solutions Dynamic Results Literature Management System (LMS) Web-based Literature Repository Search Tools Research Articles, Posters, Systematic Reviews, Guidelines Clinical Data Extraction Comparative Effectiveness & Meta Analysis E-Dossiers/Regulatory Submissions Evidence Portal (EVP) and Database Internal data, marketing materials Trial Design / Simulation Online HCP and Consumer Sites

6. What is NHANES? The National Health and Nutrition Examination Survey (NHANES) is a program of studies designed to assess the health and nutritional status of adults and children in the United States. The survey is unique in that it combines interviews and physical examinations. The NHANES interview includes demographic, socioeconomic, dietary, and health-related questions. The examination component consists of medical, dental, and physiological measurements, as well as laboratory tests administered by highly trained medical personnel.

7. What Areas are Covered? • Physical fitness and physical functioning • Reproductive history and sexual behavior • Respiratory disease (asthma, chronic bronchitis, emphysema) • Sexually transmitted diseases • Vision • Oral health • Osteoporosis • Anemia • Cardiovascular disease • Diabetes • Environmental exposures • Eye diseases • Hearing loss • Infectious diseases • Kidney disease • Nutrition • Obesity

8. Current Challenges • No way to locate data of interest in NHANES other than browsing the web site • Requires knowledge of Analytic Guidelines - each dataset may have specific analytic requirements • Analysis is not possible without statistical software package and a lot of custom programming • Even with a statistical software package data is hard to analyze (e.g. prescription data) • Steep learning curve

9. Current Steps to get to the Data