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Harmonized Protocol for Hippocampal Tracing: A Collaborative Effort

This project focuses on developing a harmonized protocol for manual hippocampal segmentation to enhance consistency and accuracy in research studies. The initiative aims to evaluate the validity of this unified protocol across various institutions and experts. Led by a collaborative workgroup consisting of prominent researchers and advisors from the EADC and ADNI, the project involves harmonizing existing segmentation protocols and comparing them against the gold standard of manual segmentation. The ultimate goal is to establish a reliable and standardized method for hippocampal tracing that can be utilized in clinical trials and population-based studies to assess disease progression and treatment efficacy effectively.

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Harmonized Protocol for Hippocampal Tracing: A Collaborative Effort

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  1. AAN –Toronto, April 11, 2010 Development of a harmonized protocol for hippocampal tracing An EADC-ADNI joint effortINTRODUCTION

  2. BACKGROUND Hippocampal volume as a diagnostic marker Structure: MR hippo volumetry Function: FDG PET Amyloid deposits: PET Biochemistry: CSF tau/Abeta Dubois, Feldman et al., Lancet Neurol 2007

  3. BACKGROUND The effect of segmentation protocols on hippocampal volume Geuze et al., Mol Psychiatry 2005;10:147-59

  4. BACKGROUND Hippocampal volume as an outcome measure in trials of disease modifiers * Chv= Change in hippocampal volume; § referenced link not working; n.m. = not mentioned

  5. BACKGROUND Hippocampal volume (manual segmentation) as gold standard for automated segmentation algorithms Morey et al., NeuroImage 2009

  6. AIMS To Harmonize Available Protocols for Manual Hippocampal Segmentation To Test the Validity of the Harmonized Protocol

  7. THE WORKGROUP EADC F Barkhof/P Scheltens Amsterdam B Dubois/S Leherici Paris N Fox London GB Frisoni Brescia H Hampel/J Pantel Frankfurt A Simmons London H Soininen Kuopio S Teipel Rostock LO Wahlund Stockholm

  8. THE WORKGROUP ADNI CR Jack Jr Rochester, MN G Barzokis UCLA, CA D Bennet Chicago, IL J Csernansky NorthW U, WA C DeCarli UC Davis, CA M De Leon New York, NY J Kaye Portland, OR R Killiany Boston USM, MA PM Thompson LoNI, UCLA, CA M Weiner/S Mueller UCSF/VAMC

  9. THE WORKGROUP other relevant hippo experts R Camicioli Univ Alberta, Canada J O’Brien NewCastle, UK J Pruessner McGill, QC, Canada

  10. THE WORKGROUP Advisory Boards EADC-ADNI P.I.s B Vellas Toulouse, France B Winblad Stockholm, Sweden M Weiner UCSF, US Population-based studies M Breteler / T Den Heijer Rotterdam Scan Study P Sachdev / JJ Maller PATH through life L Launer NIA Bethesda W Jagust Berkeley

  11. THE WORKGROUP Boards Statistical Board S Duchesne Laval Univ, Canada L Collins MNI, McGill, Montreal P Pasqualetti AFaR, Rome Clinical Advisor PJ Visser Maastricht, The Netherlands Dissemination/Education G Waldemar Copenhagen, Denmark

  12. THE WORKGROUP Personnel in Brescia Marina Boccardi psychologist, PhD Rossana Ganzola psychologist Enrica Cavedo psychologist Michela Pievani mathematician Anna Caroli mathematician Alberto Redolfi bioinformaticist

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