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ANEMIA LEUKEMIA

ANEMIA LEUKEMIA. Schema of bloodforming. Definition of а nemia. Anemia – it is decrease of erythrocytes amount and hemoglobin in unite of blood volume , which is accompanied also qualitative changes of erythrocytes. Pathogenetic classification of anemias. 1. Posthemorrhagic anemia

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ANEMIA LEUKEMIA

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  1. ANEMIALEUKEMIA

  2. Schema of bloodforming

  3. Definitionof аnemia • Anemia – it is decrease of erythrocytesamountandhemoglobininunite of blood volume, whichis accompanied also qualitative changes of erythrocytes

  4. Pathogenetic classification ofanemias • 1. Posthemorrhagicanemia • 2. Hemolyticanemia • 3. Аnemia as a result of erythropoiesis disorder

  5. Acute posthemorrhagic аnemia Causes: • 1. Wounding of vessels • 2. Gastrointestinal bleeding 3. Dysmenorrhea • 4. Rupture oftube uterine (Fallopii) • 5. Tuberculousis of lung

  6. Chronicalposthemorrhagic аnemia Causes • 1. Stomach ulcer • 2. Cancerof stomach • 3. Hemorrhoid • 4. Uterine bleeding • 5. Renal bleeding • 6. Nasal bleeding According to colour index - hypochromic

  7. Acquiredhemolytic аnemia 1. Toxic 2. Immune 3. Мechanical 4. Acquired membranopathy

  8. Тoxichemolytic аnemia Poisoning withhemolytic poisons: • Arsenous hydrogen • Acetoacid lead • Phosphorus • Nitribenzol • Phenylhydrasin • Cholic acids • Mushroom poison • Snakepoison

  9. Immunehemolytic аnemia • 1. Autoimmune anemia • 2. Posttrasfusional anemia • а) transfusion of АВ0-incompatibleblood • б) transfusionRh-incompatibleblood • 3. Hemolytic anemia of newborn

  10. Acquired hemolytic аnemia. Reticulocytosis

  11. Hereditaryhemolytic аnemia • 1. Enzymopathy • 2. Hemoglobinopathy • 3. Membranopathy

  12. Enzymopathies • 1. Deficiency ofglucose-6- phosphatedehydrogenase • 2. Deficiencypyruvatekinase

  13. Drugs, causinghemolysis erythrocytesinG-6-PHDGinsuficiency • Sulfanilamides • Antimalaricmedicines • Aminosalicylicacid • Phenacetin • Vitamines С and К • Аspirininlargedoses

  14. Hemolytic anemiadue to pyruvatekinaseinsuficiency.Reticulocytosis

  15. Hemoglobinopathies Sickle cell anemia Thalassemia: • α-thalassemia • ß-thalassemia

  16. Sickle cell anemia - blood

  17. Sickle cell anemia – blood:of the left– sickle-likeerythrocytes,of the right– test tohypoxia

  18. Small (heterozygous) thalassemia – blood

  19. Small (heterozygous) thalassemia – blood

  20. Greater (homozygous) thalassemiaCooley’s – blood

  21. Greater (homozygous)anemiaCooley’s -blood

  22. Membranopathy. Hereditary microspherocytosis - blood

  23. MembranopathyHereditary elliptocytosis – blood

  24. Membranopathy – blood

  25. Membranopathy – blood

  26. MembranopathyHereditaryacanthosis– blood

  27. MembranopathyHereditary echynocytosis - blood

  28. Anemiasas a result deficiency of erythropoiesis • Iron-deficiencyanemia • В12-deficiency anemia • Metaplastic anemia • Hypoplastic anemia • Sideroblastic anemia

  29. Iron-deficiency anemia - bloodd

  30. Iron-deficiencyanemia – blood

  31. В12-deficiencyanemia – blood

  32. В12-deficiencyanemia – bonemarrow

  33. Perniciousanemia – b. marrowBasophilic megaloblastes

  34. В12-deficiencyanemia – b. marrowStages of megaloblast development

  35. Pernicious anemia – b. marrowStages of megaloblast development

  36. Megaloblastes. Megalocytes.Jolly’s bodies. Cabot’s rings

  37. LEUKEMIA

  38. Definitionleukemia Leukemia – it is tumor, whicherise from bloodforming cellsand primarydemagesbonemarrow

  39. Classification of leucosis Acute leucosis myeloid lymphoid Chronicalleucosis myeloid lymphoid

  40. Acutemyeloidleucosis Undifferentiated Myeloblasticwithout maturate Мyeloblastic с maturate Promyelocytic Myelomonoblastic Monoblastic Erythroblastic Megakaryoblastic

  41. Histochemicalcriteries of acuteleucosis differentiation 1. Peroxidase reaction 2. Acidicphosphatase reaction 3. Unspecific esterase reaction 4. Lipid reaction 5. Compound carbohydrates reaction

  42. Reaction ofmyeloblastesand other cells ofneutrophiliclineofperoxidase

  43. Reactionof monoblastesofα-naphtylacetateesterase

  44. Reaction ofmyeloblastesandmonoblastesof acidicphosphatase

  45. Reactionwith blacksudanof lipids

  46. Acidic sulfurated mucopolysaccharides reaction

  47. Acuteundifferentiatedleucosis - blood

  48. Acuteundifferentiated leucosis – b. marrow

  49. Acuteundifferentiated leucosis– b. marrow. Аtypical cells

  50. Acutemyeloblastic – b. marrow. Initialstage. Granularmyeloblast. Aur’s stab

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