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Seroprevalance of Hepatitis C in Turkey (%) (Anti-HCV positivity in donors)

Adana (n:8310) Antalya (n:16.410) Bursa (n:16.512) Erzurum (n:24.870) İstanbul (n:108.000) Trabzon (n:22.300) Ankara (n:14.372). Seroprevalance of Hepatitis C in Turkey (%) (Anti-HCV positivity in donors).

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Seroprevalance of Hepatitis C in Turkey (%) (Anti-HCV positivity in donors)

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  1. Adana (n:8310) Antalya (n:16.410) Bursa (n:16.512) Erzurum (n:24.870) İstanbul (n:108.000) Trabzon (n:22.300) Ankara (n:14.372) Seroprevalance of Hepatitis C in Turkey (%)(Anti-HCV positivity in donors)

  2. Annual Anti-HCV Positivity rate at Istanbul–Çapa Red Crescent Blood Bank Year Total nbr of blood units Seropositive (%) 1997 73,959 0.4 1998 62,786 0.6 1999 55,953 0.4 2000 51,460 0.4 2001 51,037 0.4 Overall, 0.3% of 457,240 units from Red Crescent blood banks positive for Anti-HCV.

  3. Characteristics of seropositive cases No difference by sex or educational status  Age 18-28 : 0,2% 29-30 : 0,3% 40-50 : 0,4% 51-55 : 0,6%  First-time donors : 0,2 %  Soldiers : 2,4 %  Professional donors : 20 %

  4. Anti-HCV Seropositivity in different groups (%)-I Haemodialysis patients (overall 41% positive in 2073 cases) n% Ankara 418 34,7 Bursa 110 82,8 Adana 180 14,4 İstanbul 150 36,0 İzmir 81 49,3 Diyarbakır 55 32,7 Kayseri 76 32,9 Sivas 65 56,9 Trabzon 80 20

  5. Anti-HCV Seropositivity in different groups (%)-II %  Health personnel (n>3290) 0,9  Sex workers (n> 800) 4,8  Prisoners 3,1  Diabetic patients 11,6  Hepatocellular carsinoma 12,5-29  Renal transplantation 12,5-52,7  Cryptogenic cirrhosis 26,9  Talassemia patients 16,6-57,1  IV drug users 54,8

  6. Diagnostic methods of HCV infections in Turkey • Screening : Anti-HCV ELİSA (3rd,4th generation kits) • Monitorization of treatment (HCV –RNA viral load) ; Cobas –Amplicor monitoring / b.DNA-Bayer • Treatment :INF + Ribavirin • Genotype distribution :> 70 %: 1b

  7. Liver cirrhosis in Turkey (%) Years Aetiology 1983-89 1990-93 1994-97 (n=616) (n=436) (n=393) Viral 42,9 56,7 59,5 Cryptogenic 41,2 22,7 16,8 Alcoholic 8,9 12,6 10,9 Misc. 7 8 12,8

  8. Viral Agents in Liver Cirrhosis (%) 1990-93 1994-1997 HBV 56,5 42,6 HCV 25,2 34,5 HDV 14,6 15,7 HBV + HCV 3,7 1,2 Alcoholic + Viral __ 6

  9. Etiologic Distribution of the Chronic Hepatitis (%) 1991-1994 1994-1997 ( n: 296) (n: 527) Type B 56 46,5 Type C 23 35 Cryptogenic C.H. 9 8,9 Type B+D 6,8 4,5 Type B+C 3 3 Autoimmune 1,5 1,5 Drug induced 0,7 0,2 B+C+D _ 0,4

  10. Summary Hepatitis B still keeps the first place in the etiology of chronic hepatitis in Turkey. The ratio of hepatitis B and D decreases among the other causes of chronic hepatitis. The ratio of hepatitis C increases as a cause of chronic hepatitis. The ratio of crytogenic and autoimmune hepatitis remain the same.

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