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Studies of DOXIL for AIDS-related KS (Pre-HAART)

Studies of DOXIL for AIDS-related KS (Pre-HAART). Note: A total of 10 DOXIL studies of varying design were completed for AIDS related KS. Publications of DOXIL for AIDS-related KS (HAART Era). Results of Randomized Studies of Liposomal Anthracyclines.

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Studies of DOXIL for AIDS-related KS (Pre-HAART)

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  1. Studies of DOXIL for AIDS-related KS(Pre-HAART) Note: A total of 10 DOXIL studies of varying design were completed for AIDS related KS

  2. Publications of DOXIL for AIDS-related KS(HAART Era)

  3. Results of Randomized Studies of Liposomal Anthracyclines NOTE: # = number; eval. = evaluable; A = Adriamycin (doxorubicin); B = bleomycin; V = vincristine; NS = not significant; NR = not reported. * includes complete and partial responses † this study reported mean survival times of 239 days for DOXIL, versus 160 days for bleomycin and vincristine.

  4. Documentation for ACTG Criteria • Biopsy • Cutaneous lesions • Number • Character (flat or raised) • Tumor-associated edema • 3-5 marker lesions • Bi-dimensional measurement • Visceral lesions • Radiographic evaluation • Bronchoscopy and endoscopy

  5. Clinical Presentation of Patients Treated with DOXIL • Advanced KS with: • No prior HAART • HAART intolerant or failure • Virologic and immunologic response to HAART • Rapid KS progression on starting HAART (IRIS)

  6. Response of Kaposi’s Sarcoma to DOXIL

  7. Response of Kaposi’s Sarcoma to DOXIL

  8. Response of Kaposi’s Sarcoma to DOXIL

  9. Kaposi Sarcoma Incidence AIDS-related KS approval Study 30-38 Source: SEER Cancer Statistics Review, 1975-2002

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