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Pituitary DWARFISM

Pituitary DWARFISM. By Caitlin Antoch and Robert Wood. Which Gland is involved? . The Pituitary Gland is a pea- sized gland located at the base of the skull. This gland secretes many hormones and is referred to as the “Master Gland” because it controls hormone functions all over the body.

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Pituitary DWARFISM

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  1. Pituitary DWARFISM By Caitlin Antoch and Robert Wood

  2. Which Gland is involved? • The Pituitary Gland is a pea- sized gland located at the base of the skull. • This gland secretes many hormones and is referred to as the “Master Gland” because it controls hormone functions all over the body. The Pituitary Gland

  3. Which hormones are involved? • The Human Growth Hormone (hGH or GH) is secreted from the Anterior lobe of the Pituitary Gland and is responsible for growth in children.

  4. How does the Growth Hormone (GH) normally function? The Anterior Pituitary Gland produces human growth hormone (hGH or GH), also known as somatotropin. GH binds to receptors on liver cells and they release insulin- like growth factor- 1 (IGF-1). This hormone causes body cells to grow and stimulates protein synthesis within cartilage, bones, and muscle. This hormone increases the growth rate of bones and muscles during childhood. GH also has many effects on metabolism GH stimulates the rate at which amino acids enter cells and protein synthesis occurs. GH stimulates fat and carbohydrate metabolism.

  5. Negative Feedback loop of the Growth Hormone

  6. Amount of Growth Hormone

  7. What Causes this Disorder? Hyposecretion (underproduction) of the Growth Hormone during growing years causes slow bone growth and the epiphyseal plates close before normal height is reached. This condition is known as Dwarfism.

  8. Proportionate Dwarfism • Proportionate (Pituitary) Dwarfism results from medical conditions limiting overall growth and development. • In a person with Proportionate Dwarfism, the head, trunk, and limbs are all small but they are proportionate to each other. • Growth Hormone deficiency is a common cause for this disorder. • It occurs when the Pituitary Gland fails to produce an adequate amount of Growth Hormone.

  9. WORKS CIted http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002159/ Tortora, Gerald J. and Sandra Reybolds Grabowski. Principles of Anatomy and Physiology. New York: Harper Collins College, 1993. Print. http://www.google.com/imgres?q=Pituitary+gland+growth+hormone&hl=en&biw=1280&bih=856&gbv=2&tbm=isch&tbnid=lRiQRQxMQnlKaM:&imgrefurl=http://kids.britannica.com/elementary/art-87270&docid=nxVXrQ_A0NsWoM&imgurl=http://media.web.britannica.com/eb-media/13/93313-034-70936098.jpg&w=550&h=400&ei=h2JzT--hIcry2QW0sLDUDg&zoom=1&iact=rc&dur=125&sig=103961430341098122716&page=1&tbnh=148&tbnw=203&start=0&ndsp=21&ved=1t:429,r:5,s:0&tx=168&ty=46 http://www.neurosurgery.pitt.edu/minc/skullbase/pituitary/index.html http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/P/Pituitary.html

  10. Works Cited cont. • http://www.google.com/imgres?q=pituitary+gland+location&hl=en&sa=X&gbv=2&biw=1280&bih=856&tbm=isch&tbnid=7Zhu1Te9JriTSM:&imgrefurl=http://thebrainlabs.com/brain.shtml&docid=oU2pwkKKoNfr0M&imgurl=http://thebrainlabs.com/Images/pituitary_gland.gif&w=237&h=261&ei=J2tzT5WTKqLE2wWO4tX5Dg&zoom=1&iact=hc&vpx=685&vpy=546&dur=3906&hovh=208&hovw=189&tx=148&ty=85&sig=103961430341098122716&page=1&tbnh=147&tbnw=133&start=0&ndsp=24&ved=1t:429,r:21,s:0 • http://www.google.com/imgres?q=pituitary+gland+growth+hormone&um=1&hl=en&sa=N&gbv=2&biw=1280&bih=856&tbm=isch&tbnid=zMRyk9YvNeNcmM:&imgrefurl=http://www.medindia.net/patients/patientinfo/acromegaly-glandsinvolved.htm&docid=MKTg3pQXzNmJtM&imgurl=http://www.medindia.net/patients/patientinfo/Images/GrowthHarmone.gif&w=306&h=367&ei=H21zT7XkL8Gs2gWIwLnaDg&zoom=1&iact=rc&dur=141&sig=103961430341098122716&page=1&tbnh=153&tbnw=127&start=0&ndsp=21&ved=1t:429,r:7,s:0&tx=100&ty=70

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