Regulation of LTβR Signaling by RelA and RelB in Different Cell Types
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This study categorizes the regulation of LTβR signaling in wild-type and relA-/- or relB-/- cells, highlighting the distinct roles of RelA and RelB. Results show their requirement for mediating LTβR signaling, with differences in regulation patterns among cell types.
Regulation of LTβR Signaling by RelA and RelB in Different Cell Types
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Presentation Transcript
A wild-type Σ: 528 Category I Regulated only in wt cells Category II Regulated in wt and relA-/-cells relA-/- 30 30 366 Category III Regulated in wt and relB-/-cells Category IV Regulated in wt, relA-/-,and relB-/-cells 102 relB-/- B Cat I/1 Cat I/2 Both RelA and RelB are required for mediating LTβR signaling (- regulation) n=205 Both RelA and RelB are required for mediating LTβR signaling (+ regulation) n=161 Cat II/1 Cat II/2 Cat II/3 Cat II/4 RelB mediates LTβR signaling (+ regulation) n=13 RelB mediates LTβR signaling (- regulation) n=17 n=0 n=0 Cat III/1 Cat III/2 Cat III/3 Cat III/4 RelA mediates LTβR signaling (+ regulation) n=54 RelA mediates LTβR signaling (- regulation) n=43 n=3 n=2 Cat IV/3 Cat IV/4 Cat IV/5 Cat IV/1 Cat IV/2 n=0 n=0 n=0 RelA and RelB redundantly mediate LTβR signaling (- regulation) n=10 RelA and RelB redundantly mediate LTβR signaling (+ regulation) n=20 n=0 n=0 n=0 Cat IV/6 Cat IV/7 Cat IV/8
