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Unraveling the Impact of FICZ on IL-17A, IFNg, and TNF Pathways in AhR knockout Mice

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This study investigates how FICZ affects IL-17A, IFNg, and TNF pathways in AhR knockout mice. The research delves into the intricate interactions between these molecules and analyzes the consequences of FICZ exposure on immune responses. By examining the molecular mechanisms underlying these pathways, the study sheds light on the complex interplay between AhR and cytokine signaling in the immune system. The findings provide valuable insights into the potential therapeutic implications of modulating these pathways in various disease conditions.

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Unraveling the Impact of FICZ on IL-17A, IFNg, and TNF Pathways in AhR knockout Mice

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  1. FICZ 4 4 10 10 4 4 1.0 10 10 0.1 1.3 0.1 3.5 0.4 4.5 0.6 3 3 10 10 3 3 10 10 2 2 10 10 2 2 10 10 4 10 4 30.5 11.8 10 1 1 10 10 16.9 9.8 1 1 10 10 4 10.7 91.7 10 88.2 6.8 3 10 90.5 5.5 87.1 7.7 3 10 0 0 10 10 0 0 10 10 0 1 2 3 4 0 1 2 3 4 10 10 10 10 10 10 10 10 10 10 3 0 1 2 3 4 0 1 2 3 4 10 10 10 10 10 10 10 10 10 10 10 2 10 2 10 4 4 10 10 4 10 0.8 1.0 0.1 0.1 2 0.4 11 8.7 1.4 10 1 10 1 10 3 3 10 10 55.9 3 1.8 10 62.1 11.3 1 10 0 10 0 10 0 1 2 3 4 10 10 10 10 10 2 2 10 10 0 1 2 3 4 10 10 10 10 10 2 10 0 10 0 1 2 3 4 10 10 10 10 10 1 1 10 10 1 10 89.4 9.7 6.1 92.8 3.7 82.4 85 7.5 0 0 10 10 0 10 0 1 2 3 4 0 1 2 3 4 10 10 10 10 10 10 10 10 10 10 0 1 2 3 4 10 10 10 10 10 IL-17A IL-17A IFNg TNF Supplem.Fig.3 a) Wt AhR ko b) + FICZ

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