'Tnf' diaporamas de présentation

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Individualisierte Medizin am Inselspital Genetik und Perioperative Medizin

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Drugs used in inflammatory bowel disease and biological and immune therapy of IBD

Drugs used in inflammatory bowel disease and biological and immune therapy of IBD. Prof. Hanan Hagar Pharmacology Unit College of Medicine. Inflammatory Bowel Diseases (IBD) is a group of inflammatory conditions of the small intestine and colon . auto-immune disorders

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Drugs used in inflammatory bowel disease and biological and immune therapy of IBD

Drugs used in inflammatory bowel disease and biological and immune therapy of IBD. Prof. Hanan Hagar Pharmacology Unit College of Medicine. Inflammatory Bowel Diseases (IBD) is a group of inflammatory conditions of the small intestine and colon . auto-immune disorders

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Outline

Expanding the Research Domains of Rheumatoid Arthritis Clinical Databases: The Promise of Pharmacogenetics Jeffrey Greenberg, MD, MPH NYU Hospital for Joint Diseases New York University School of Medicine December 2006. Outline. Why Pharmacogenetics Case Study: TNF Antagonists

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487 views • 35 slides

Artrite reumatoide

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Con arguments: Maxime DOUGADOS

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Cytotoxic and Immunologic Effects of Silver Nanoparticles

Cytotoxic and Immunologic Effects of Silver Nanoparticles. Shaun Cote. What are Nanoparticles?. Any substance that has one dimension of 1-100 nanometers Commonly used nanoparticles include colloidal gold and titanium dioxide (TiO 2 ). Nano Scale. Why is this important?.

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MabThera in daily clinical practice European Patient Cohorts and Registries MIRA Update

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MabThera in daily clinical practice European Patient Cohorts and Registries MIRA Update

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(from Cyster, Immunol. Rev., 2003. 195:5-14)

(from Cyster, Immunol. Rev., 2003. 195:5-14). White pulp nodule within spleen. (from Fu and Chaplin, Annu. Rev. Immunol. 1999. 17:399-433). Follicular dendritic cells (FDC)

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30:1 Adv0

Figure 1. A. B. C. Uninfected 3:1 10:1 30:1 60:1. Uninfected 10:1 30:1 60:1. 30:1 Adv0. 30:1 AdvGFP. Figure 2. Cytosolic I ?B? p42/44 MAP kinases NF ?B activation on EMSA. Uninf AdvI ?B? Adv0. Figure 3. Adv0. 180. 160. AdvI ?B?. 140. 120. 100. % production.

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Supplementary Figure 1:

Supplementary Figure 1:. Supplementary Figure 2: NFkB silencing prevents IL-6, TNF and CCL2 expression. Supplementary Figure 3:. A. B. Supplementary Figure 4: ERK inhibition in macrophages prevents adhesion.

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TNF Signaling Pathway

TNF Signaling Pathway. SIGMA-ALDRICH. TNF Signaling Pathway

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Relative mRNA level MGP/18S

*. 6. MGP. EV. Pi + + + + TNF - - + + EV MGP EV MGP. 30. 4. Relative mRNA level MGP/18S. *. 20. 2. Calcium/protein ( ? g/mg). 10. 0. EV. MGP. 0. Pi. Pi+TNF.

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MIF

MIF. MIF. MMP. IL-18. IFN - g. IL-2. Angiogenesis VEGF, FGF, HGF IL-8, angipoietin-1 Stromal cell derived GF TNF , TGF (indirect). Angiostatic IL-12, IFN -a b g, PF4. Adhesion molecules ICAM-1,2 VAM-1 *b -i ntegrin LAF-3 *P-selectin. BMP MIF. MIF. Anti-glucocorticoid effects.

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Death Domain

BLyS/ TALL1/ THANK/BAFF. TWEAK/APO3L. APRIL. EDA1. EDA2. TRANCE/RANKL. CD95L. TRAIL. CD70. Soluble OPG. EDAR. CD95. DcR1. RANK. CD27. XEDAR. DR4,5,cR2. Death Domain. FN14/. TWEAKR. SELECTED TNF SUPERFAMILY MEMBERS. Type II Glycoproteins. LT ? 1 ? 2 or LT ? 2 ? 1. CD154.

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D1+TNF- ?

D6+TNF- ?. D1+TNF- ?. D6+DXR. D1+DXR. TNF- ?. CTR. D1. D6. DXR. MW. 65 kDa. NF-kB. LAMIN. 65 kDa. Additional file 3 Figure S2 Effects of D1 and D6 on NFkB expression in neuroblastoma cell line. Legend

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TOLEROGENIC BONE MARROW-DERIVED DENDRITIC CELLS MODULATE ALLERGIC REACTIVITY

21. 11. 21. 25. 21. 23. 22. 28. 17. 24. 41. 41. 25. 37. 62. BACKGROUND.

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