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Understanding TNF Superfamily Members: Key Players in Immune Regulation

This article explores the role of members of the TNF superfamily, including TWEAK, BAFF, and TRAIL, in immune regulation. We discuss the various receptors such as CD95, RANK, and their soluble forms, detailing their impact on cell signaling and apoptosis. The significance of glycoproteins like LTα and their receptors in the immune response is also highlighted. Furthermore, the interactions of these molecules in cancer therapy and autoimmune diseases are examined, emphasizing the therapeutic potential of targeting these pathways.

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Understanding TNF Superfamily Members: Key Players in Immune Regulation

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  1. BLyS/ TALL1/ THANK/BAFF TWEAK/APO3L APRIL EDA1 EDA2 TRANCE/RANKL CD95L TRAIL CD70 Soluble OPG EDAR CD95 DcR1 RANK CD27 XEDAR DR4,5,cR2 Death Domain FN14/ TWEAKR SELECTED TNF SUPERFAMILY MEMBERS Type II Glycoproteins LT12 or LT21 CD154 CD134L/OX40L TL1A CD137L/41BBL TNF LIGHT CD153 GITRL Soluble (LT)3 Soluble TNF SolubleDDcR3 LMP1 TACI p55 TNFR CD120a p75 TNFR CD120b LTR HVEM DR3 CD30 CD137/41BB GITR BCMA BAFFR CD134/OX40 CD40 Type I or III Glycoproteins

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