bone diseases

1. bone diseases Lecture no. 3 Prepared by Dr.Salah Mohammad Fatih MBChB,DMRD,FIBMS(radiology)

3. Multiple focal lesions

4. Metastases & multiple myeloma are most common cause of obvious multiple lytic lesions in the bone.

5. metastases Is the commonest malignant bone tumor. Those bones contains red marrow are the commonest site to be affected, namely spine, skull, ribs, pelvis, humeri & femora.

6. Types of metastases Lytic secondary deposit; Sclerotic metastases; Mixed lytic & sclerotic secondary deposits;

7. Sclerotic bone metastases • Most commonly arises from prostate cancer, but also arise from breast, lung and carcinoid

8. CT: Osteolytic lesions Most commonly arises from breast, lung, thyroid, renal, melanoma, and gastrointestinal malignancies

9. CT: Mixed lesions  / mixture of osteoblastic and osteolytic lesions  / seen in breast cancer

10. Lytic secondary deposit; in the adult most commonly from , breast & bronchus & less commonly from carcinoma of the thyroid, renal, colon in the children from neuroblastoma. Radiologically appear as a well-defined or ill-defined areas of bone destruction without sclerotic rim. Sclerotic metastases; in the men most commonly from prostate & in the female from Ca breast, it appear as ill-defined areas of increased density of varying sizes with ill-defined margin. Mixed lytic & sclerotic secondary deposits; they are most commonly from Ca breast

11. Notes; bone expansion uncommon in metastases except in Ca thyroid & kidney. periosteal reaction is uncommon with metastases except in neuroroblastoma. Isotope scan is much more sensitive than plain film in detecting bone metastases & if multiple areas of increased activity are seen in a patient with known primary Ca, then the Dx of metastases is virtually certain .

12. MRI is better than isotope scan for detecting & it shows more metastases but is more difficult to survey the whole skeleton with MRI. CT less sensitive than MRI for detecting metastases, but can demonstrate lytic & sclerotic metastases & the image should be reviewed on bone windows .

13. Multiple myeloma They are more commonly seen in active heamopoetic areas . It is resemble lytic metastases but it is often better defined. Diffuse marrow involvement may cause generalized loss of bone density producing a picture similar to that of osteoporosis. Most meyloma deposite show increased activity on isotope scan

15. Generalize decreased bone density(osteopenia)

16. Main causes of generalized decrease in bone density; • Osteoporosis. • Osteomalacia. • Hyperparathyroidism. • Multiple myeloma.

17. Radiographic density of the bone depend on the amount of calcium present in the bone. • decrease in bone calcium lead to decrease in bone density.

18. osteoporosis • Osteoporosis is the consequence of a deficiency of protein matrix(osteoid) & decrease amount of the normal bone (i.e. loss of bone mass) while remaining bone is normally mineralized (microstructure of the bone remain normal & histologically also normal)

19. Osteoporosis predispose to fractures , specially vertebral bodies & hips.

20. Main Causes of osteoporosis 1-Idiopathic; according to the age, subdivided to; • Juvenile • Senile • Postmenopausal; up to 50% of female over 60 years of age have osteoporosis. 2-Cushing’s disease & steroid therapy. 3-disuse

21. Radiological features • Change in bone density usually unapparent until 30-50% of the bone mass has been lost. • Decreased cortical thickness. • Decreased no. of the trabeculae present in the bone.

22. Generalized decrease in bone density Prminent vertical trabicuale Empty box VB compression fracture

23. Changes best seen in the spine. • Resorption of the horizontal trabeculae. • Empty box ; apparent increased end plate density due to Resorption of the spongy bone. • VB compression fracture; wedged or biconcave types with apparent widening of the disc spaces

24. Disuse osteoporosis • Local decreased bone density caused by localized pain or immobilization of a fracture

25. Indistinctness of the cortex of the right femoral head and osteopenia of the entire femoral head

26. Rickets & osteomalacia • There is poor mineralization of osteoid. • If occur before epiphyseal closure, it known as rickets. • If occur in adult ,it known as osteomalacia.

27. This patient shows abnormal bone density, with coarsened abnormal trabeculae in a generalized pattern. Even more prominently, we see widened and irregular metaphyses Rickets

28. The anterior ends of the ribs are quite abnormal in this patient, with splaying at the costochondral junction Rickets (rachitic rosary)

29. Radiological finding of rickets • The changes are maximal where bone growth is occur, so they best seen in the knees, wrists & ankles • Loss of provisional zone of calcification. • Indistinct metaphyses & metaphyses become irregular and cupped. • Wide growth plate. • decreased bone density. • Deformities of the bones occur because of bone softening. • Greenstick fractures are common

30. This patient has generalized osteopenia. In addition, several of the right lower ribs demonstrate transverse fractures with a wide lucency at the fracture site (arrow). Your diagnosis? Osteomalacia with looser’s zone

31. osteomalacia • Radiological findings; • Decreased bone density. • Looser’s zones; are short lucent band running through the cortex at the Rt angles & may have sclerotic margin, commonest site are scapula, medial aspect of femurs,& pubic rami & ribs • Bone deformity due to bone softening e.g. biconcave vertebra bodies

32. Hyperparathyroidism • Cause mobilization of the calcium from the bone, resulting in a decreased bone density. • Hyperparathyroidism could be primary hyperparathyroidism (90 percent due to an adenoma) or secondary hyperparathyroidism due to renal dysfunction.

33. Many patients with primary hyperparathyroidism present with renal stone & minority present with radiologically detected bone changes.

34. Radiological features of hyperparathyroidism

35. Extensive subperiostealresorption is seen on both the radial and ulnar side of the middle phalanges (white arrows, left hand). brown tumor in the left distal ulna as well as the left trapezoid (black arrows, left hand).a as well as in the right head of the third metacarpal and the base of the proximal phalanx of the fifth digit (black arrows, right hand).

36. Features of both primary & secondary hyperparathyroidism are similar except that brown tumors are much rarer & vascular calcification is commoner in secondary hyperparathyroidism

37. vascular calcification is the predominant finding Hyperparathyroidism from renal osteodystrophy.

38. hyperparathyroidism • Generalized decrease in bone density. • The hallmark of hyperparathyroidism is subperiosteal bone Resorption. • Soft tissue calcification; vascular & chondrocalcification sometime occur. • Brown tumor are occasionally present which are small lytic lesion which could be single or multiple

39. Generalized increase in bone density

40. Causes; • Sclerotic metastases, commonest cause. • Osteopetrosis (marble bone disease); congenital, bone sclerotic & brittle leading to multiple fractures. • Myelosclerosis;there is replacement of the bone marrow by fibrous tissue & lay down of the bone which is usually appear as patchy areas of sclerosis

41. This child has extremely dense bones throughout the body. There is abnormal modeling at the metaphyses with flaring. Your diagnosis? Osteopetrosis

42. Alteration in trabecular pattern & changes in the shape • Paget’s disease • hemolytic anemia

43. 1-Paget’s disease • Usually is the chance finding in elderly. • One or more bones may be affected, the usual sites are pelvis, spine , skull & long bones

44. this patient gives a classic appearance of advanced mixed lytic and sclerotic Paget's disease , bone expansion,loss of corticomedullary differentiation and anterior bowing of the tibia Paget’s disease

45. typical picture-frame appearance of VB due to the enlargement and mixed lytic sclerotic pattern. Paget's dsease

46. Radiological finding of Paget’s disaese; • Cardinal features are ; • thickening of the trabeculae & the cortex, causing increase in bone density & loss of corticomedullary differentiation. • Enlargement of the affected bone. • Bone softening causes bowing & deformity of the bones & pathological fracture may occur

47. 2-Hemolytic anemia • There are many types of hemolytic anemia , but radiological changes are seen in main two types; thalassaemia & sickle cell disease. • Both causes bone marrow hyperplasia, but sickle cell disease also may show evidence of bone infarction & infection

48. dense striations in a very widened diploic space of the cranium (hair-on-end appearance). Additionally, note that the paranasal sinuses are obliterated Thalassemia

49. The metacarpals and phalanges are squared and show a very thinned endosteal cortex with abnormal density. Resorption of some trabeculae & remaining trabeculae become thick & prominent. Thalassemia

50. Radiological features of marrow hyperplasia • Thinning of the cortex & bone expansion. • Resorption of some trabeculae & remaining trabeculae become thick & prominent. • In the skull; it cause widening of the deploe & perpendicular striation occur which is known as ‘ Hair-on-end’. • The ribs may enlarged & phalanges may become rectangular.