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Impact of FGFR3 Signaling on Apoptosis and MAPK Pathways in BxPC-3 and PANC-1 Cells

This study investigates the roles of FGFR3 isoforms (FGFR3-IIIb and FGFR3-IIIc) and various signaling proteins (P-STAT1, P-STAT3, P-ERK, P-JNK, and P-p38) in the regulation of apoptosis and MAPK pathways in pancreatic cancer cells BxPC-3 and PANC-1. We examine the interplay between pro-apoptotic (BAX) and anti-apoptotic (BCL2) factors, along with the phosphorylation status of retinoblastoma protein (P-RB) and CREB in response to FGFR3 signaling. Supplemental figures further elucidate these findings.

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Impact of FGFR3 Signaling on Apoptosis and MAPK Pathways in BxPC-3 and PANC-1 Cells

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  1. FGFR3-IIIc FGFR3-IIIb CTRL P-STAT1 P-STAT3 GAPDH FGFR3-IIIc FGFR3-IIIb CTRL FGFR3 FGFR3 P-ERK P-ERK MAPKs Total ERK Total ERK P-JNK STATs MAPKs Total JNK P-p38 BxPC-3 Total p38 P-STAT1 STATs P-STAT3 BAX Apoptosis BCL2 P-pRB 795 Total pRB P-Creb GAPDH PANC-1 Supplemental Figure 7

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