Introduction to the Knowledge Discovery Department Institute for Infocomm Research Limsoon Wong

1. Introduction to the Knowledge Discovery Department Institute for Infocomm Research Limsoon Wong Deputy Executive Director (Research) I2R: Imagination to reality

2. mission: Advance Infocomm Technology to benefit humanity and create prosperity for S’pore core values:Dedication to excellence, passion for innovation, integrity & respect size: 350 RSEs BMRC SERC IMRE IME DSI IHPC ICES SIMTECH I2R

3. EDB-iDA ICT Cluster Map

4. I2R Services & Applications Communications & Devices Media Infocomm Security Knowledge Discovery E-Service Infrastructure Media Processing Media Semantics Human Computer Interaction • Cryptography • Network security • Information security • Service Composition • Service creation • Data-in-Network • Connected Home • Secure Filesystem/ DBMS • Mutimedia Signal Processing • Noise Reduction • Media Adaptation • Mixed Media Mining • Natural Language Synergy • Pervasive Media • Perceptual Human Media • Speech & Dialogue • Biometrics • Knowledge Extraction • Decision Systems • Discovery Systems Embedded Systems Radio Systems Networking Digital Wireless Lightwave • Terminal • Software Defined Radio • Transceiver system • Antenna • Radio Over Fiber • UWB • Modem Technology • Multiple Access • Smart Antenna Array Systems • Network Design • WDM Systems • Fibre Technology Organization • Next Gen IP • End-to-end QoS • Mobile Middleware • Mobile Adhoc Networks • Mobile Sensor Networks

5. Services & Applications Information Security Knowledge Discovery E-services Infrastructure Service Creation Policy-based framework for creating/managing application, storage and network services Knowledge Extraction Data fusion from sensors, knowledge extraction technologies. Applications in functional genomics & gene regulatory networks Cryptography Cryptographic techniques for privacy protection, high-speed encryption, group digital signatures and new public key infrastructure Data-in-Network High-speed data cache and IPC on optical network Decision Systems Data Mining technologies. Applications in clinical data analysis and protein network analysis Information Security Techniques for privacy protection, peer-to-peer system security and media security Service Composition Tech for consumers to create personalized services from component e-services Discovery Systems Data cleansing, modeling & knowledge management technologies. Applications in immunoinformatics and venominformatics Connected HomeReference design for an OSGi compliant residential gateway Network Security Wireless network security, intrusion detection and technology to trace attackers Secure Filesystem Steganographic and reliable file systems/DBMSs on externally managed platforms

6. Protein Interactions Extraction (PIES) 8 years of bioinformatics R&D in Singapore MHC-Peptide Binding (PREDICT) Gene Expression & Medical Record Datamining (PCL) Molecular Connections Cleansing & Warehousing (FIMM) Integration Technology (Kleisli) Gene Feature Recognition (Dragon) Venom Informatics Biobase GeneticXchange 1994 1996 1998 2002 2000 ISS LIT/I2R KRDL History

7. Directions • Knowledge Extraction • gene regulatory network • endocrinology info system Translate inspiration from biological systems into advancement in life and computing sciences Advance data mining technologies in decision systems for complex problems • Technologies for • data mining • data fusion • data cleansing • data modeling • knowledge extraction • knowledge management • Discovery Systems • immunoinformatics • venominformatics • Decision Systems • clinical data analysis • protein interaction • network

8. Decision Systems Lab Highlight Yeoh et al. Cancer Cell 1, 133-143, 2002 PCL Technology • Machine learning of emerging patterns • Rules learned by computers easily understood by doctors • High accuracy

9. Discovery Systems Lab Highlight • Brusic et al. Cytokine-related genes identi-fied from the RIKEN full-length mouse cDNA dataset. Genome Res.(in press) • Silva et al. Identifica-tion of novel human disease-related gene candidates from the RIKEN full-length mouse cDNA dataset. Genome Res. (in press) FANTOM2 Consortium Nature 420, 563-573, 2002

10. KE Lab Highlight • Dragon Promoter Finder and Dragon Gene Start Finder • Very high accuracy, order of magnitude improvement • Licensed to Biobase, integrated with TRANSPLORER and TRANSFAC

11. Qualification • 18 full-time staff (9 PhD, 6MSc, and 3 BSc) and 10-20 students at any time • Our faculty holds adjunct professorial positions (SANBI, Univ. of Canberra, NUS, and NTU) • During the last two years 8 MSc students graduated under our supervision

12. Professional Activities • Journals: 3 chief editorial roles, and 9 editorial board memberships • International Conferences (last 5 years): 4 conference chairs, and more than 40 program committee roles, 10 keynote lectures, and dozens of plenary talks

13. Track Record • Publications (last 5 years):More than 100 in last 5 years, many in top journals (e.g. Nature, PNAS, Cancer Cell, JACM) and top conferences. • Patents (last 5 years): 1 granted and 6 pending • Commercialization (last 5 years): 2 international start-ups and one software licensed

14. People Decision Systems Head: Dr. See-Kiong Ng PI: A/Prof. Limsoon Wong, Dr. Jinyan Li Staff: Huiqing Liu, Zhuo Zhang, Soon-Heng Tan Post Doc: Dr. Shaowu Meng Discovery Systems Head: A/Prof. Vladimir Brusic Staff: Judice Koh, Guanglan Zhang, Seng Hong Seah Post Doc: Dr. Rekha Pillai Knowledge Extraction Head: Prof. Vladimir B. Bajic Staff: Hao Han, SPT Krishnan, Allen Chong, Sin Lam Tan Post Doc: Dr. Suisheng Tang

15. Here they are...