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Inflammatory Colitis

Inflammatory Colitis. Acute: <6 weeks. Chronic: >6 weeks. Chronic ischemic colitis. IBD*** - chronic changes Crypt distortion Crypt atrophy Paneth cell metaplasia Lympho-plasmacytic infiltrate. Infectious*** -neutrophils in LP -no sign of chronicity (see IBD) -toxins: C. diff, E. coli

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Inflammatory Colitis

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  1. Inflammatory Colitis Acute: <6 weeks Chronic: >6 weeks Chronic ischemic colitis • IBD*** • -chronic changes • Crypt distortion • Crypt atrophy • Paneth cell metaplasia • Lympho-plasmacytic infiltrate Infectious*** -neutrophils in LP -no sign of chronicity (see IBD) -toxins: C. diff, E. coli -stool culture (ova + parasite) Ischemia -neutrophils -hemorrhage in LP -no chronicity Ulcerative colitis -mucosal (superficial) -no granulomas -distal colon -limited to colon (backwash ileitis) -cancer risk  Crohn’s Disease -transmural (deep) -granulomas -proximal colon -extra colonic (upper GI tract) -cancer risk *** indicates most common cause LP = lamina propria

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